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A small-molecule competitive inhibitor of phosphatidic acid binding by the AAA+ protein NSF/Sec18 blocks the SNARE-priming stage of vacuole fusion.
Sparks RP, Arango AS, Starr ML, Aboff ZL, Hurst LR, Rivera-Kohr DA, Zhang C, Harnden KA, Jenkins JL, Guida WC, Tajkhorshid E, Fratti RA. Sparks RP, et al. Among authors: hurst lr. J Biol Chem. 2019 Nov 15;294(46):17168-17185. doi: 10.1074/jbc.RA119.008865. Epub 2019 Sep 12. J Biol Chem. 2019. PMID: 31515268 Free PMC article.
The Central Polybasic Region of the Soluble SNARE (Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor) Vam7 Affects Binding to Phosphatidylinositol 3-Phosphate by the PX (Phox Homology) Domain.
Miner GE, Starr ML, Hurst LR, Sparks RP, Padolina M, Fratti RA. Miner GE, et al. Among authors: hurst lr. J Biol Chem. 2016 Aug 19;291(34):17651-63. doi: 10.1074/jbc.M116.725366. Epub 2016 Jun 30. J Biol Chem. 2016. PMID: 27365394 Free PMC article.
Correction: A small-molecule competitive inhibitor of phosphatidic acid binding by the AAA+ protein NSF/Sec18 blocks the SNARE-priming stage of vacuole fusion.
Sparks RP, Arango AS, Starr ML, Aboff ZL, Hurst LR, Rivera-Kohr DA, Zhang C, Harnden KA, Jenkins JL, Guida WC, Tajkhorshid E, Fratti RA. Sparks RP, et al. Among authors: hurst lr. J Biol Chem. 2022 Nov;298(11):102576. doi: 10.1016/j.jbc.2022.102576. Epub 2022 Oct 15. J Biol Chem. 2022. PMID: 36257250 Free PMC article. No abstract available.
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