Otting G - Search Results

1

1.3 Å Crystal Structure of E. coli Peptidyl-Prolyl Isomerase B with Uniform Substitution of Valine by (2S,3S)-4-Fluorovaline Reveals Structure Conservation and Multiple Staggered Rotamers of CH₂F Groups.

Frkic RL, Tan YJ, Maleckis A, Chilton NF, Otting G, Jackson CJ. Frkic RL, et al. Among authors: otting g. Biochemistry. 2024 Oct 15;63(20):2602-2608. doi: 10.1021/acs.biochem.4c00345. Epub 2024 Sep 24. Biochemistry. 2024. PMID: 39316701

2

Conformational Preferences of the Non-Canonical Amino Acids (2S,4S)-5-Fluoroleucine, (2S,4R)-5-Fluoroleucine, and 5,5'-Difluoroleucine in a Protein.

Frkic RL, Tan YJ, Abdelkader EH, Maleckis A, Tarcoveanu E, Nitsche C, Otting G, Jackson CJ. Frkic RL, et al. Among authors: otting g. Biochemistry. 2024 Jun 4;63(11):1388-1394. doi: 10.1021/acs.biochem.4c00081. Epub 2024 May 14. Biochemistry. 2024. PMID: 38742763

3

(2S,4S)-5-Fluoroleucine, (2S,4R)-5-Fluoroleucine, and 5,5'-Difluoroleucine in Escherichia coli PpiB: Protein Production, ¹⁹F NMR, and Ligand Sensing Enhanced by the γ-Gauche Effect.

Tan YJ, Abdelkader EH, Tarcoveanu E, Maleckis A, Nitsche C, Otting G. Tan YJ, et al. Among authors: otting g. Biochemistry. 2024 Jun 4;63(11):1376-1387. doi: 10.1021/acs.biochem.4c00080. Epub 2024 May 16. Biochemistry. 2024. PMID: 38753308

4

Synthesis of ¹³C/¹⁹F/²H labeled indoles for use as tryptophan precursors for protein NMR spectroscopy.

Maleckis A, Herath ID, Otting G. Maleckis A, et al. Among authors: otting g. Org Biomol Chem. 2021 Jun 16;19(23):5133-5147. doi: 10.1039/d1ob00611h. Org Biomol Chem. 2021. PMID: 34032255

5

Through-Space Scalar ¹⁹F-¹⁹F Couplings between Fluorinated Noncanonical Amino Acids for the Detection of Specific Contacts in Proteins.

Orton HW, Qianzhu H, Abdelkader EH, Habel EI, Tan YJ, Frkic RL, Jackson CJ, Huber T, Otting G. Orton HW, et al. Among authors: otting g. J Am Chem Soc. 2021 Nov 24;143(46):19587-19598. doi: 10.1021/jacs.1c10104. Epub 2021 Nov 15. J Am Chem Soc. 2021. PMID: 34780162

6

Synthesis of fluorinated leucines, valines and alanines for use in protein NMR.

Maleckis A, Abdelkader EH, Herath ID, Otting G. Maleckis A, et al. Among authors: otting g. Org Biomol Chem. 2022 Mar 23;20(12):2424-2432. doi: 10.1039/d2ob00145d. Org Biomol Chem. 2022. PMID: 35262139

7

Electrostatic Contribution to ¹⁹F Chemical Shifts in Fluorotryptophans in Proteins.

Maxwell M, Tan YJ, Lee R, Huber T, Otting G. Maxwell M, et al. Among authors: otting g. Biochemistry. 2023 Nov 21;62(22):3255-3264. doi: 10.1021/acs.biochem.3c00408. Epub 2023 Nov 7. Biochemistry. 2023. PMID: 37934875

8

Protein engineering with unnatural amino acids.

Zhang WH, Otting G, Jackson CJ. Zhang WH, et al. Among authors: otting g. Curr Opin Struct Biol. 2013 Aug;23(4):581-7. doi: 10.1016/j.sbi.2013.06.009. Epub 2013 Jul 5. Curr Opin Struct Biol. 2013. PMID: 23835227 Review.

9

Genetic Encoding of Cyanopyridylalanine for In-Cell Protein Macrocyclization by the Nitrile-Aminothiol Click Reaction.

Abdelkader EH, Qianzhu H, George J, Frkic RL, Jackson CJ, Nitsche C, Otting G, Huber T. Abdelkader EH, et al. Among authors: otting g. Angew Chem Int Ed Engl. 2022 Mar 21;61(13):e202114154. doi: 10.1002/anie.202114154. Epub 2022 Feb 11. Angew Chem Int Ed Engl. 2022. PMID: 35102680 Free PMC article.

10

Genetic Encoding of N⁶-(((Trimethylsilyl)methoxy)carbonyl)-l-lysine for NMR Studies of Protein-Protein and Protein-Ligand Interactions.

Abdelkader EH, Qianzhu H, Tan YJ, Adams LA, Huber T, Otting G. Abdelkader EH, et al. Among authors: otting g. J Am Chem Soc. 2021 Jan 20;143(2):1133-1143. doi: 10.1021/jacs.0c11971. Epub 2021 Jan 5. J Am Chem Soc. 2021. PMID: 33399460

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