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Knockdown of microglial iron import gene, Slc11a2, worsens cognitive function and alters microglial transcriptional landscape in a sex-specific manner in the APP/PS1 model of Alzheimer's disease.
Robertson KV, Rodriguez AS, Cartailler JP, Shrestha S, Schleh MW, Schroeder KR, Valenti AM, Kramer AT, Harrison FE, Hasty AH. Robertson KV, et al. Among authors: schleh mw. J Neuroinflammation. 2024 Sep 27;21(1):238. doi: 10.1186/s12974-024-03238-w. J Neuroinflammation. 2024. PMID: 39334471 Free PMC article.
Insulin at the intersection of thermoregulation and glucose homeostasis.
Winn NC, Schleh MW, Garcia JN, Lantier L, McGuinness OP, Blair JA, Hasty AH, Wasserman DH. Winn NC, et al. Among authors: schleh mw. Mol Metab. 2024 Mar;81:101901. doi: 10.1016/j.molmet.2024.101901. Epub 2024 Feb 13. Mol Metab. 2024. PMID: 38354854 Free PMC article.
Impaired suppression of fatty acid release by insulin is a strong predictor of reduced whole-body insulin-mediated glucose uptake and skeletal muscle insulin receptor activation.
Schleh MW, Ryan BJ, Ahn C, Ludzki AC, Van Pelt DW, Pitchford LM, Chugh OK, Luker AT, Luker KE, Samovski D, Abumrad NA, Burant CF, Horowitz JF. Schleh MW, et al. Acta Physiol (Oxf). 2025 Jan;241(1):e14249. doi: 10.1111/apha.14249. Epub 2024 Nov 1. Acta Physiol (Oxf). 2025. PMID: 39487600 Free PMC article.
Metaflammation in obesity and its therapeutic targeting.
Schleh MW, Caslin HL, Garcia JN, Mashayekhi M, Srivastava G, Bradley AB, Hasty AH. Schleh MW, et al. Sci Transl Med. 2023 Nov 22;15(723):eadf9382. doi: 10.1126/scitranslmed.adf9382. Epub 2023 Nov 22. Sci Transl Med. 2023. PMID: 37992150 Free PMC article. Review.
Both moderate- and high-intensity exercise training increase intramyocellular lipid droplet abundance and modify myocellular distribution in adults with obesity.
Schleh MW, Ahn C, Ryan BJ, Chugh OK, Luker AT, Luker KE, Gillen JB, Ludzki AC, Van Pelt DW, Pitchford LM, Zhang T, Rode T, Howton SM, Burant CF, Horowitz JF. Schleh MW, et al. Am J Physiol Endocrinol Metab. 2023 Nov 1;325(5):E466-E479. doi: 10.1152/ajpendo.00093.2023. Epub 2023 Sep 20. Am J Physiol Endocrinol Metab. 2023. PMID: 37729021 Free PMC article.
20 results