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Page 1
Efficient synthesis for each of the eight stereoisomers of the iminosugars lentiginosine and 1,4-dideoxy-1,4-imino-D-arabinitol (DAB).
Liotta LJ, Antoine J, Brammer Basta LA, Campbell AS, Cole GY, Demick Brazile KA, Dogal Gardner NM, Fitzgerald ME, Francois JEK, French BM, Garafola SL, Giannetti CA, Granatosky EA, Harney AM, Hummel JT, Joyce AP, Keylor MH, Khubchandani JA, Korzeniecki C, Lieberman DC, Litterio JM, Maiorano MO, Marshall JF, McCarthy KA, Mendes Vieira A, Miller RM, Morrison ER, Moura SP, Neumann DF, Oliveira AF, Pace NJ, Plouffe JX, Pomfret MN, Reardon KN, Sheller-Miller SM, Smith MJ, Sullivan JL, Sweeney SW, Tougas KL. Liotta LJ, et al. Among authors: keylor mh. Carbohydr Res. 2024 Nov;545:109280. doi: 10.1016/j.carres.2024.109280. Epub 2024 Sep 19. Carbohydr Res. 2024. PMID: 39326205
Discovery and Optimization of N-Heteroaryl Indazole LRRK2 Inhibitors.
Logan KM, Kaplan W, Simov V, Zhou H, Li D, Torres L, Morriello GJ, Acton JJ, Pio B, Chen YH, Keylor MH, Johnson R, Kattar SD, Chau R, Yan X, Ardolino M, Zarate C, Otte KM, Palte RL, Xiong T, McMinn SE, Lin S, Neelamkavil SF, Liu P, Su J, Hegde LG, Woodhouse JD, Moy LY, Ciaccio PJ, Piesvaux J, Zebisch M, Henry C, Barker J, Wood HB, Kennedy ME, DiMauro EF, Fell MJ, Fuller PH. Logan KM, et al. Among authors: keylor mh. J Med Chem. 2024 Sep 26;67(18):16807-16819. doi: 10.1021/acs.jmedchem.4c01627. Epub 2024 Sep 4. J Med Chem. 2024. PMID: 39231262
Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease.
Kattar SD, Gulati A, Margrey KA, Keylor MH, Ardolino M, Yan X, Johnson R, Palte RL, McMinn SE, Nogle L, Su J, Xiao D, Piesvaux J, Lee S, Hegde LG, Woodhouse JD, Faltus R, Moy LY, Xiong T, Ciaccio PJ, Pearson K, Patel M, Otte KM, Leyns CEG, Kennedy ME, Bennett DJ, DiMauro EF, Fell MJ, Fuller PH. Kattar SD, et al. Among authors: keylor mh. J Med Chem. 2023 Nov 9;66(21):14912-14927. doi: 10.1021/acs.jmedchem.3c01486. Epub 2023 Oct 20. J Med Chem. 2023. PMID: 37861679
Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease.
Candito DA, Simov V, Gulati A, Kattar S, Chau RW, Lapointe BT, Methot JL, DeMong DE, Graham TH, Kurukulasuriya R, Keylor MH, Tong L, Morriello GJ, Acton JJ, Pio B, Liu W, Scott JD, Ardolino MJ, Martinot TA, Maddess ML, Yan X, Gunaydin H, Palte RL, McMinn SE, Nogle L, Yu H, Minnihan EC, Lesburg CA, Liu P, Su J, Hegde LG, Moy LY, Woodhouse JD, Faltus R, Xiong T, Ciaccio P, Piesvaux JA, Otte KM, Kennedy ME, Bennett DJ, DiMauro EF, Fell MJ, Neelamkavil S, Wood HB, Fuller PH, Ellis JM. Candito DA, et al. Among authors: keylor mh. J Med Chem. 2022 Dec 22;65(24):16801-16817. doi: 10.1021/acs.jmedchem.2c01605. Epub 2022 Dec 7. J Med Chem. 2022. PMID: 36475697
Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors.
Keylor MH, Gulati A, Kattar SD, Johnson RE, Chau RW, Margrey KA, Ardolino MJ, Zarate C, Poremba KE, Simov V, Morriello GJ, Acton JJ, Pio B, Yan X, Palte RL, McMinn SE, Nogle L, Lesburg CA, Adpressa D, Lin S, Neelamkavil S, Liu P, Su J, Hegde LG, Woodhouse JD, Faltus R, Xiong T, Ciaccio PJ, Piesvaux J, Otte KM, Wood HB, Kennedy ME, Bennett DJ, DiMauro EF, Fell MJ, Fuller PH. Keylor MH, et al. J Med Chem. 2022 Jan 13;65(1):838-856. doi: 10.1021/acs.jmedchem.1c01968. Epub 2021 Dec 30. J Med Chem. 2022. PMID: 34967623
Synthesis of Vitisins A and D Enabled by a Persistent Radical Equilibrium.
Romero KJ, Keylor MH, Griesser M, Zhu X, Strobel EJ, Pratt DA, Stephenson CRJ. Romero KJ, et al. Among authors: keylor mh. J Am Chem Soc. 2020 Apr 8;142(14):6499-6504. doi: 10.1021/jacs.0c01714. Epub 2020 Mar 24. J Am Chem Soc. 2020. PMID: 32156107 Free PMC article.
Chemistry and Biology of Resveratrol-Derived Natural Products.
Keylor MH, Matsuura BS, Stephenson CR. Keylor MH, et al. Chem Rev. 2015 Sep 9;115(17):8976-9027. doi: 10.1021/cr500689b. Epub 2015 Apr 2. Chem Rev. 2015. PMID: 25835567 Free PMC article. Review. No abstract available.
11 results