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Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1+ progenitor CD8+ T cells to improve immunotherapy.
Markowitz GJ, Ban Y, Tavarez DA, Yoffe L, Podaza E, He Y, Martin MT, Crowley MJP, Sandoval TA, Gao D, Martin ML, Elemento O, Cubillos-Ruiz JR, McGraw TE, Altorki NK, Mittal V. Markowitz GJ, et al. Among authors: tavarez da. Nat Immunol. 2024 Oct;25(10):1884-1899. doi: 10.1038/s41590-024-01963-1. Epub 2024 Sep 26. Nat Immunol. 2024. PMID: 39327500
Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1+ progenitor CD8+ T cells to improve checkpoint blockade.
Markowitz GJ, Ban Y, Tavarez DA, Yoffe L, Podaza E, He Y, Martin MT, Crowley MJP, Sandoval TA, Gao D, Martin ML, Elemento O, Cubillos-Ruiz JR, McGraw TE, Altorki NK, Mittal V. Markowitz GJ, et al. Among authors: tavarez da. Res Sq [Preprint]. 2023 Sep 21:rs.3.rs-3356477. doi: 10.21203/rs.3.rs-3356477/v1. Res Sq. 2023. Update in: Nat Immunol. 2024 Oct;25(10):1884-1899. doi: 10.1038/s41590-024-01963-1 PMID: 37790365 Free PMC article. Updated. Preprint.
Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer.
Crowley MJP, Bhinder B, Markowitz GJ, Martin M, Verma A, Sandoval TA, Chae CS, Yomtoubian S, Hu Y, Chopra S, Tavarez DA, Giovanelli P, Gao D, McGraw TE, Altorki NK, Elemento O, Cubillos-Ruiz JR, Mittal V. Crowley MJP, et al. Among authors: tavarez da. Nat Commun. 2023 Jan 9;14(1):120. doi: 10.1038/s41467-022-35584-9. Nat Commun. 2023. PMID: 36624093 Free PMC article.