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UPF1-like helicase grip on nucleic acids dictates processivity.
Kanaan J, Raj S, Decourty L, Saveanu C, Croquette V, Le Hir H. Kanaan J, et al. Among authors: le hir h. Nat Commun. 2018 Sep 14;9(1):3752. doi: 10.1038/s41467-018-06313-y. Nat Commun. 2018. PMID: 30218034 Free PMC article.
Nonsense-mediated mRNA decay involves two distinct Upf1-bound complexes.
Dehecq M, Decourty L, Namane A, Proux C, Kanaan J, Le Hir H, Jacquier A, Saveanu C. Dehecq M, et al. Among authors: le hir h. EMBO J. 2018 Nov 2;37(21):e99278. doi: 10.15252/embj.201899278. Epub 2018 Oct 1. EMBO J. 2018. PMID: 30275269 Free PMC article.
Novel approaches to study helicases using magnetic tweezers.
Ruiz-Gutierrez N, Rieu M, Ouellet J, Allemand JF, Croquette V, Le Hir H. Ruiz-Gutierrez N, et al. Among authors: le hir h. Methods Enzymol. 2022;673:359-403. doi: 10.1016/bs.mie.2022.03.035. Epub 2022 Apr 22. Methods Enzymol. 2022. PMID: 35965012 Free article.
EJC core component MLN51 interacts with eIF3 and activates translation.
Chazal PE, Daguenet E, Wendling C, Ulryck N, Tomasetto C, Sargueil B, Le Hir H. Chazal PE, et al. Among authors: le hir h. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):5903-8. doi: 10.1073/pnas.1218732110. Epub 2013 Mar 25. Proc Natl Acad Sci U S A. 2013. PMID: 23530232 Free PMC article.
A role for AKT1 in nonsense-mediated mRNA decay.
Palma M, Leroy C, Salomé-Desnoulez S, Werkmeister E, Kong R, Mongy M, Le Hir H, Lejeune F. Palma M, et al. Among authors: le hir h. Nucleic Acids Res. 2021 Nov 8;49(19):11022-11037. doi: 10.1093/nar/gkab882. Nucleic Acids Res. 2021. PMID: 34634811 Free PMC article.
65 results