Hurdle JG - Search Results

1

Chemical genetic analysis of enoxolone inhibition of Clostridioides difficile toxin production reveals adenine deaminase and ATP synthase as antivirulence targets.

Marreddy RKR, Phelps GA, Churion K, Picker J, Powell R, Cherian PT, Bowling JJ, Stephan CC, Lee RE, Hurdle JG. Marreddy RKR, et al. Among authors: hurdle jg. J Biol Chem. 2024 Nov;300(11):107839. doi: 10.1016/j.jbc.2024.107839. Epub 2024 Sep 27. J Biol Chem. 2024. PMID: 39343002 Free PMC article.

2

Progress in the discovery of treatments for C. difficile infection: A clinical and medicinal chemistry review.

Tsutsumi LS, Owusu YB, Hurdle JG, Sun D. Tsutsumi LS, et al. Among authors: hurdle jg. Curr Top Med Chem. 2014;14(1):152-75. doi: 10.2174/1568026613666131113154753. Curr Top Med Chem. 2014. PMID: 24236721 Free PMC article. Review.

3

N-substituted 3-acetyltetramic acid derivatives as antibacterial agents.

Yendapally R, Hurdle JG, Carson EI, Lee RB, Lee RE. Yendapally R, et al. Among authors: hurdle jg. J Med Chem. 2008 Mar 13;51(5):1487-91. doi: 10.1021/jm701356q. Epub 2008 Feb 19. J Med Chem. 2008. PMID: 18281930

4

A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents.

Hurdle JG, Lee RB, Budha NR, Carson EI, Qi J, Scherman MS, Cho SH, McNeil MR, Lenaerts AJ, Franzblau SG, Meibohm B, Lee RE. Hurdle JG, et al. J Antimicrob Chemother. 2008 Nov;62(5):1037-45. doi: 10.1093/jac/dkn307. Epub 2008 Aug 7. J Antimicrob Chemother. 2008. PMID: 18693235 Free PMC article.

5

Novel acyl phosphate mimics that target PlsY, an essential acyltransferase in gram-positive bacteria.

Grimes KD, Lu YJ, Zhang YM, Luna VA, Hurdle JG, Carson EI, Qi J, Kudrimoti S, Rock CO, Lee RE. Grimes KD, et al. Among authors: hurdle jg. ChemMedChem. 2008 Dec;3(12):1936-45. doi: 10.1002/cmdc.200800218. ChemMedChem. 2008. PMID: 19016283 Free PMC article.

6

Discovery, synthesis, and biological evaluation of piperidinol analogs with anti-tuberculosis activity.

Sun D, Scherman MS, Jones V, Hurdle JG, Woolhiser LK, Knudson SE, Lenaerts AJ, Slayden RA, McNeil MR, Lee RE. Sun D, et al. Among authors: hurdle jg. Bioorg Med Chem. 2009 May 15;17(10):3588-94. doi: 10.1016/j.bmc.2009.04.005. Epub 2009 Apr 9. Bioorg Med Chem. 2009. PMID: 19386501 Free PMC article.

7

Evaluation of analogs of reutericyclin as prospective candidates for treatment of staphylococcal skin infections.

Hurdle JG, Yendapally R, Sun D, Lee RE. Hurdle JG, et al. Antimicrob Agents Chemother. 2009 Sep;53(9):4028-31. doi: 10.1128/AAC.00457-09. Epub 2009 Jul 6. Antimicrob Agents Chemother. 2009. PMID: 19581456 Free PMC article.

8

A simple in vitro PK/PD model system to determine time-kill curves of drugs against Mycobacteria.

Budha NR, Lee RB, Hurdle JG, Lee RE, Meibohm B. Budha NR, et al. Among authors: hurdle jg. Tuberculosis (Edinb). 2009 Sep;89(5):378-85. doi: 10.1016/j.tube.2009.08.002. Epub 2009 Sep 11. Tuberculosis (Edinb). 2009. PMID: 19748318 Free PMC article.

9

Structural studies of pterin-based inhibitors of dihydropteroate synthase.

Hevener KE, Yun MK, Qi J, Kerr ID, Babaoglu K, Hurdle JG, Balakrishna K, White SW, Lee RE. Hevener KE, et al. Among authors: hurdle jg. J Med Chem. 2010 Jan 14;53(1):166-77. doi: 10.1021/jm900861d. J Med Chem. 2010. PMID: 19899766 Free PMC article.

10

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections.

Hurdle JG, O'Neill AJ, Chopra I, Lee RE. Hurdle JG, et al. Nat Rev Microbiol. 2011 Jan;9(1):62-75. doi: 10.1038/nrmicro2474. Nat Rev Microbiol. 2011. PMID: 21164535 Free PMC article. Review.

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