Powell R - Search Results

1

Chemical genetic analysis of enoxolone inhibition of Clostridioides difficile toxin production reveals adenine deaminase and ATP synthase as antivirulence targets.

Marreddy RKR, Phelps GA, Churion K, Picker J, Powell R, Cherian PT, Bowling JJ, Stephan CC, Lee RE, Hurdle JG. Marreddy RKR, et al. Among authors: powell r. J Biol Chem. 2024 Nov;300(11):107839. doi: 10.1016/j.jbc.2024.107839. Epub 2024 Sep 27. J Biol Chem. 2024. PMID: 39343002 Free PMC article.

2

Bexarotene - a novel modulator of AURKA and the primary cilium in VHL-deficient cells.

Chowdhury P, Powell RT, Stephan C, Uray IP, Talley T, Karki M, Tripathi DN, Park YS, Mancini MA, Davies P, Dere R. Chowdhury P, et al. Among authors: powell rt. J Cell Sci. 2018 Dec 14;131(24):jcs219923. doi: 10.1242/jcs.219923. J Cell Sci. 2018. PMID: 30518623 Free PMC article.

3

High-throughput screening against protein:protein interaction interfaces reveals anti-cancer therapeutics as potent modulators of the voltage-gated Na⁺ channel complex.

Wadsworth PA, Folorunso O, Nguyen N, Singh AK, D'Amico D, Powell RT, Brunell D, Allen J, Stephan C, Laezza F. Wadsworth PA, et al. Sci Rep. 2019 Nov 15;9(1):16890. doi: 10.1038/s41598-019-53110-8. Sci Rep. 2019. PMID: 31729429 Free PMC article.

4

Therapeutically actionable signaling node to rescue AURKA driven loss of primary cilia in VHL-deficient cells.

Chowdhury P, Perera D, Powell RT, Talley T, Tripathi DN, Park YS, Mancini MA, Davies P, Stephan C, Coarfa C, Dere R. Chowdhury P, et al. Among authors: powell rt. Sci Rep. 2021 May 17;11(1):10461. doi: 10.1038/s41598-021-89933-7. Sci Rep. 2021. PMID: 34002003 Free PMC article.

5

A High-throughput Approach to Identify Effective Systemic Agents for the Treatment of Anaplastic Thyroid Carcinoma.

Henderson YC, Mohamed ASR, Maniakas A, Chen Y, Powell RT, Peng S, Cardenas M, Williams MD, Bell D, Zafereo ME, Wang RJ, Scherer SE, Wheeler DA, Cabanillas ME, Hofmann MC, Johnson FM, Stephan CC, Sandulache V, Lai SY. Henderson YC, et al. Among authors: powell rt. J Clin Endocrinol Metab. 2021 Sep 27;106(10):2962-2978. doi: 10.1210/clinem/dgab424. J Clin Endocrinol Metab. 2021. PMID: 34120183 Free PMC article.

6

Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition.

Zhao N, Powell RT, Yuan X, Bae G, Roarty KP, Stossi F, Strempfl M, Toneff MJ, Johnson HL, Mani SA, Jones P, Stephan CC, Rosen JM. Zhao N, et al. Nat Commun. 2021 Jul 12;12(1):4262. doi: 10.1038/s41467-021-24545-3. Nat Commun. 2021. PMID: 34253738 Free PMC article.

7

Author Correction: Therapeutically actionable signaling node to rescue AURKA driven loss of primary cilia in VHL-deficient cells.

Chowdhury P, Perera D, Powell RT, Talley T, Tripathi DN, Park YS, Mancini MA, Davies P, Stephan C, Coarfa C, Dere R. Chowdhury P, et al. Among authors: powell rt. Sci Rep. 2021 Aug 30;11(1):17657. doi: 10.1038/s41598-021-97270-y. Sci Rep. 2021. PMID: 34462545 Free PMC article. No abstract available.

8

Combined inhibition of HMGCoA reductase and mitochondrial complex I induces tumor regression of BRAF inhibitor-resistant melanomas.

de Groot E, Varghese S, Tan L, Knighton B, Sobieski M, Nguyen N, Park YS, Powell R, Lorenzi PL, Zheng B, Stephan C, Gopal YNV. de Groot E, et al. Among authors: powell r. Cancer Metab. 2022 Feb 22;10(1):6. doi: 10.1186/s40170-022-00281-0. Cancer Metab. 2022. PMID: 35193687 Free PMC article.

9

deepOrganoid: A brightfield cell viability model for screening matrix-embedded organoids.

Powell RT, Moussalli MJ, Guo L, Bae G, Singh P, Stephan C, Shureiqi I, Davies PJ. Powell RT, et al. SLAS Discov. 2022 Apr;27(3):175-184. doi: 10.1016/j.slasd.2022.03.004. Epub 2022 Mar 18. SLAS Discov. 2022. PMID: 35314378 Free article.

10

Combined TRIP13 and Aurora Kinase Inhibition Induces Apoptosis in Human Papillomavirus-Driven Cancers.

Ghosh S, Mazumdar T, Xu W, Powell RT, Stephan C, Shen L, Shah PA, Pickering CR, Myers JN, Wang J, Frederick MJ, Johnson FM. Ghosh S, et al. Among authors: powell rt. Clin Cancer Res. 2022 Oct 14;28(20):4479-4493. doi: 10.1158/1078-0432.CCR-22-1627. Clin Cancer Res. 2022. PMID: 35972731 Free PMC article.

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