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Page 1
Chemical genetic analysis of enoxolone inhibition of Clostridioides difficile toxin production reveals adenine deaminase and ATP synthase as antivirulence targets.
Marreddy RKR, Phelps GA, Churion K, Picker J, Powell R, Cherian PT, Bowling JJ, Stephan CC, Lee RE, Hurdle JG. Marreddy RKR, et al. Among authors: stephan cc. J Biol Chem. 2024 Nov;300(11):107839. doi: 10.1016/j.jbc.2024.107839. Epub 2024 Sep 27. J Biol Chem. 2024. PMID: 39343002 Free PMC article.
Gain-of-Function Chromatin Remodeling Activity of Oncogenic FOXL2-C134W Reprograms Glucocorticoid Receptor Occupancy to Drive Granulosa Cell Tumors.
Welte T, Vuttaradhi VK, Khlebus EY, Brodsky A, Flores Legarreta A, Celestino J, Powell RT, Stephan CC, Nguyen N, Li J, Takamatsu S, Calzoncinth K, Sood AK, Gershenson DM, Futreal PA, Lawson B, Hillman RT. Welte T, et al. Among authors: stephan cc. Cancer Res. 2024 Dec 9. doi: 10.1158/0008-5472.CAN-24-2341. Online ahead of print. Cancer Res. 2024. PMID: 39652611
A transgenic mouse model of Down syndrome acute lymphoblastic leukemia identifies targetable vulnerabilities.
Junco JJ, Rochette M, Alozie M, Rashid R, Terrell M, Zorman B, Sumazin P, Rowland L, Dettorre G, Powell RT, Stephan CC, Davies PJ, Martinez-Moczygemba M, Yang JJ, Rabin KR. Junco JJ, et al. Among authors: stephan cc. Haematologica. 2024 Dec 1;109(12):4083-4088. doi: 10.3324/haematol.2023.284761. Haematologica. 2024. PMID: 39049603 Free PMC article. No abstract available.
Evolution of cisplatin resistance through coordinated metabolic reprogramming of the cellular reductive state.
Yu W, Chen Y, Putluri N, Osman A, Coarfa C, Putluri V, Kamal AHM, Asmussen JK, Katsonis P, Myers JN, Lai SY, Lu W, Stephan CC, Powell RT, Johnson FM, Skinner HD, Kazi J, Ahmed KM, Hu L, Threet A, Meyer MD, Bankson JA, Wang T, Davis J, Parker KR, Harris MA, Baek ML, Echeverria GV, Qi X, Wang J, Frederick AI, Walsh AJ, Lichtarge O, Frederick MJ, Sandulache VC. Yu W, et al. Among authors: stephan cc. Br J Cancer. 2023 Jun;128(11):2013-2024. doi: 10.1038/s41416-023-02253-7. Epub 2023 Apr 3. Br J Cancer. 2023. PMID: 37012319 Free PMC article.
A High-throughput Approach to Identify Effective Systemic Agents for the Treatment of Anaplastic Thyroid Carcinoma.
Henderson YC, Mohamed ASR, Maniakas A, Chen Y, Powell RT, Peng S, Cardenas M, Williams MD, Bell D, Zafereo ME, Wang RJ, Scherer SE, Wheeler DA, Cabanillas ME, Hofmann MC, Johnson FM, Stephan CC, Sandulache V, Lai SY. Henderson YC, et al. Among authors: stephan cc. J Clin Endocrinol Metab. 2021 Sep 27;106(10):2962-2978. doi: 10.1210/clinem/dgab424. J Clin Endocrinol Metab. 2021. PMID: 34120183 Free PMC article.
Identification of Inhibitors of Integrin Cytoplasmic Domain Interactions With Syk.
Bakthavatsalam D, Craft JW Jr, Kazansky A, Nguyen N, Bae G, Caivano AR, Gundlach CW 4th, Aslam A, Ali S, Gupta S, Lin SY, Parthiban HD, Vanderslice P, Stephan CC, Woodside DG. Bakthavatsalam D, et al. Among authors: stephan cc. Front Immunol. 2021 Jan 8;11:575085. doi: 10.3389/fimmu.2020.575085. eCollection 2020. Front Immunol. 2021. PMID: 33488575 Free PMC article.
Estrogen-induced transcription at individual alleles is independent of receptor level and active conformation but can be modulated by coactivators activity.
Stossi F, Dandekar RD, Mancini MG, Gu G, Fuqua SAW, Nardone A, De Angelis C, Fu X, Schiff R, Bedford MT, Xu W, Johansson HE, Stephan CC, Mancini MA. Stossi F, et al. Among authors: stephan cc. Nucleic Acids Res. 2020 Feb 28;48(4):1800-1810. doi: 10.1093/nar/gkz1172. Nucleic Acids Res. 2020. PMID: 31930333 Free PMC article.
28 results