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Anti-metabolite chemotherapy increases LAG-3 expressing tumor-infiltrating lymphocytes which can be targeted by combination immune checkpoint blockade.
Principe N, Phung AL, Stevens KLP, Elaskalani O, Wylie B, Tilsed CM, Sheikh F, Orozco Morales ML, Kidman J, Marcq E, Fisher SA, Nowak AK, McDonnell AM, Lesterhuis WJ, Chee J. Principe N, et al. Among authors: orozco morales ml. J Immunother Cancer. 2024 Sep 28;12(9):e008568. doi: 10.1136/jitc-2023-008568. J Immunother Cancer. 2024. PMID: 39343508 Free PMC article.
Local therapy with combination TLR agonists stimulates systemic anti-tumor immunity and sensitizes tumors to immune checkpoint blockade.
Rwandamuriye FX, Wang T, Zhang H, Elaskalani O, Kuster J, Ye X, Vitali B, Schreurs J, Orozco Morales ML, Norret M, Evans CW, Zemek RM, Iyer KS, Lesterhuis WJ, Wylie B. Rwandamuriye FX, et al. Among authors: orozco morales ml. Oncoimmunology. 2024 Aug 22;13(1):2395067. doi: 10.1080/2162402X.2024.2395067. eCollection 2024. Oncoimmunology. 2024. PMID: 39188754 Free PMC article.
CD4+ T cells drive an inflammatory, TNF-α/IFN-rich tumor microenvironment responsive to chemotherapy.
Tilsed CM, Principe N, Kidman J, Chin WL, Orozco Morales ML, Zemek RM, Chee J, Islam R, Fear VS, Forbes C, Aston WJ, Jansen M, Chopra A, Lassmann T, Nowak AK, Fisher SA, Lake RA, Lesterhuis WJ. Tilsed CM, et al. Among authors: orozco morales ml. Cell Rep. 2022 Dec 27;41(13):111874. doi: 10.1016/j.celrep.2022.111874. Cell Rep. 2022. PMID: 36577370 Free article.
What is Kindness in Science and why does it matter?
Boulter J, Orozco Morales ML, Principe N, Tilsed CM. Boulter J, et al. Among authors: orozco morales ml. Immunol Cell Biol. 2023 Feb;101(2):97-103. doi: 10.1111/imcb.12580. Epub 2022 Aug 25. Immunol Cell Biol. 2023. PMID: 36006827 Free PMC article.
PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective.
Orozco Morales ML, Rinaldi CA, de Jong E, Lansley SM, Gummer JPA, Olasz B, Nambiar S, Hope DE, Casey TH, Lee YCG, Leslie C, Nealon G, Shackleford DM, Powell AK, Grimaldi M, Balaguer P, Zemek RM, Bosco A, Piggott MJ, Vrielink A, Lake RA, Lesterhuis WJ. Orozco Morales ML, et al. iScience. 2021 Dec 4;25(1):103571. doi: 10.1016/j.isci.2021.103571. eCollection 2022 Jan 21. iScience. 2021. PMID: 34984327 Free PMC article.