Schlacher K - Search Results

1

Diet induced mitochondrial DNA replication instability in Rad51c mutant mice drives sex-bias in anemia of inflammation.

Tomaszowski KH, Chen Y, Roy S, Harris M, Zhang J, Tsai CL, Schlacher K. Tomaszowski KH, et al. Among authors: schlacher k. bioRxiv [Preprint]. 2024 Sep 21:2024.09.21.613572. doi: 10.1101/2024.09.21.613572. bioRxiv. 2024. PMID: 39345482 Free PMC article. Preprint.

2

BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability.

Longo MA, Ahmed SM, Chen Y, Tsai CL, Namjoshi S, Wang X, Perera RL, Arvai A, Lee M, Kong LR, Engl W, Shyuan W, Zhao ZW, Venkitaraman AR, Tainer JA, Schlacher K. Longo MA, et al. Among authors: schlacher k. bioRxiv [Preprint]. 2024 Sep 22:2024.09.21.614229. doi: 10.1101/2024.09.21.614229. bioRxiv. 2024. PMID: 39345573 Free PMC article. Preprint.

3

Author Correction: Hypomorphic Brca2 and Rad51c double mutant mice display Fanconi anemia, cancer and polygenic replication stress.

Tomaszowski KH, Roy S, Guerrero C, Shukla P, Keshvani C, Chen Y, Ott M, Wu X, Zhang J, DiNardo CD, Schindler D, Schlacher K. Tomaszowski KH, et al. Among authors: schlacher k. Nat Commun. 2024 Mar 12;15(1):2214. doi: 10.1038/s41467-024-46561-9. Nat Commun. 2024. PMID: 38472265 Free PMC article. No abstract available.

4

GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer.

Ye Z, Xu S, Shi Y, Cheng X, Zhang Y, Roy S, Namjoshi S, Longo MA, Link TM, Schlacher K, Peng G, Yu D, Wang B, Tainer JA, Ahmed Z. Ye Z, et al. Among authors: schlacher k. Nat Commun. 2024 Mar 8;15(1):2132. doi: 10.1038/s41467-024-46283-y. Nat Commun. 2024. PMID: 38459011 Free PMC article.

5

Targeting ATR in patients with cancer.

Ngoi NYL, Pilié PG, McGrail DJ, Zimmermann M, Schlacher K, Yap TA. Ngoi NYL, et al. Among authors: schlacher k. Nat Rev Clin Oncol. 2024 Apr;21(4):278-293. doi: 10.1038/s41571-024-00863-5. Epub 2024 Feb 20. Nat Rev Clin Oncol. 2024. PMID: 38378898 Review.

6

RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles.

Longo MA, Roy S, Chen Y, Tomaszowski KH, Arvai AS, Pepper JT, Boisvert RA, Kunnimalaiyaan S, Keshvani C, Schild D, Bacolla A, Williams GJ, Tainer JA, Schlacher K. Longo MA, et al. Among authors: schlacher k. Nat Commun. 2023 Jul 24;14(1):4445. doi: 10.1038/s41467-023-40096-1. Nat Commun. 2023. PMID: 37488098 Free PMC article.

7

Mitochondrial Replication Assay (MIRA) for Efficient in situ Quantification of Nascent mtDNA and Protein Interactions with Nascent mtDNA (mitoSIRF).

Lozen M, Chen Y, Boisvert RA, Schlacher K. Lozen M, et al. Among authors: schlacher k. Bio Protoc. 2023 May 20;13(10):e4680. doi: 10.21769/BioProtoc.4680. eCollection 2023 May 20. Bio Protoc. 2023. PMID: 37251092 Free PMC article.

8

Hypomorphic Brca2 and Rad51c double mutant mice display Fanconi anemia, cancer and polygenic replication stress.

Tomaszowski KH, Roy S, Guerrero C, Shukla P, Keshvani C, Chen Y, Ott M, Wu X, Zhang J, DiNardo CD, Schindler D, Schlacher K. Tomaszowski KH, et al. Among authors: schlacher k. Nat Commun. 2023 Mar 11;14(1):1333. doi: 10.1038/s41467-023-36933-y. Nat Commun. 2023. PMID: 36906610 Free PMC article.

9

APOBEC3A drives deaminase domain-independent chromosomal instability to promote pancreatic cancer metastasis.

Wörmann SM, Zhang A, Thege FI, Cowan RW, Rupani DN, Wang R, Manning SL, Gates C, Wu W, Levin-Klein R, Rajapakshe KI, Yu M, Multani AS, Kang Y, Taniguchi CM, Schlacher K, Bellin MD, Katz MHG, Kim MP, Fleming JB, Gallinger S, Maddipati R, Harris RS, Notta F, Ross SR, Maitra A, Rhim AD. Wörmann SM, et al. Among authors: schlacher k. Nat Cancer. 2021 Dec;2(12):1338-1356. doi: 10.1038/s43018-021-00268-8. Epub 2021 Nov 18. Nat Cancer. 2021. PMID: 35121902

10

MRE11-dependent instability in mitochondrial DNA fork protection activates a cGAS immune signaling pathway.

Luzwick JW, Dombi E, Boisvert RA, Roy S, Park S, Kunnimalaiyaan S, Goffart S, Schindler D, Schlacher K. Luzwick JW, et al. Among authors: schlacher k. Sci Adv. 2021 Dec 17;7(51):eabf9441. doi: 10.1126/sciadv.abf9441. Epub 2021 Dec 15. Sci Adv. 2021. PMID: 34910513 Free PMC article.

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