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BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability.
Longo MA, Ahmed SM, Chen Y, Tsai CL, Namjoshi S, Wang X, Perera RL, Arvai A, Lee M, Kong LR, Engl W, Shyuan W, Zhao ZW, Venkitaraman AR, Tainer JA, Schlacher K. Longo MA, et al. Among authors: tainer ja. bioRxiv [Preprint]. 2024 Sep 22:2024.09.21.614229. doi: 10.1101/2024.09.21.614229. bioRxiv. 2024. PMID: 39345573 Free PMC article. Preprint.
Chromatin remodeler BRG1 recruits huntingtin to repair DNA double-strand breaks in neurons.
Pradhan S, Bush K, Zhang N, Pandita RK, Tsai CL, Smith C, Pandlebury DF, Gaikwad S, Leonard F, Nie L, Tao A, Russell W, Yuan S, Choudhary S, Ramos KS, Elferink C, Wairkar YP, Tainer JA, Thompson LM, Pandita TK, Sarkar PS. Pradhan S, et al. Among authors: tainer ja. bioRxiv [Preprint]. 2024 Sep 20:2024.09.19.613927. doi: 10.1101/2024.09.19.613927. bioRxiv. 2024. PMID: 39345557 Free PMC article. Preprint.
Dynamics of the DYNLL1/MRE11 complex regulates DNA end resection and recruitment of the Shieldin complex to DSBs.
Zhou R, Swift ML, Syed A, Huang K, Moreau L, Tainer JA, Konstantinopoulos PA, Dâ Andrea AD, He YJ, Chowdhury D. Zhou R, et al. Among authors: tainer ja. bioRxiv [Preprint]. 2023 Mar 27:2023.03.27.534416. doi: 10.1101/2023.03.27.534416. bioRxiv. 2023. Update in: Nat Struct Mol Biol. 2023 Oct;30(10):1456-1467. doi: 10.1038/s41594-023-01074-9 PMID: 37034578 Free PMC article. Updated. Preprint.
ASCC1 structures and bioinformatics reveal a novel helix-clasp-helix RNA-binding motif linked to a two-histidine phosphodiesterase.
Chinnam NB, Thapar R, Arvai AS, Sarker AH, Soll JM, Paul T, Syed A, Rosenberg DJ, Hammel M, Bacolla A, Katsonis P, Asthana A, Tsai MS, Ivanov I, Lichtarge O, Silverman RH, Mosammaparast N, Tsutakawa SE, Tainer JA. Chinnam NB, et al. Among authors: tainer ja. J Biol Chem. 2024 Jun;300(6):107368. doi: 10.1016/j.jbc.2024.107368. Epub 2024 May 14. J Biol Chem. 2024. PMID: 38750793 Free PMC article.
468 results