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Page 1
BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability.
Longo MA, Ahmed SM, Chen Y, Tsai CL, Namjoshi S, Wang X, Perera RL, Arvai A, Lee M, Kong LR, Engl W, Shyuan W, Zhao ZW, Venkitaraman AR, Tainer JA, Schlacher K. Longo MA, et al. Among authors: venkitaraman ar. bioRxiv [Preprint]. 2024 Sep 22:2024.09.21.614229. doi: 10.1101/2024.09.21.614229. bioRxiv. 2024. PMID: 39345573 Free PMC article. Preprint.
Selective Aurora A-TPX2 Interaction Inhibitors Have In Vivo Efficacy as Targeted Antimitotic Agents.
Stockwell SR, Scott DE, Fischer G, Guarino E, Rooney TPC, Feng TS, Moschetti T, Srinivasan R, Alza E, Asteian A, Dagostin C, Alcaide A, Rocaboy M, Blaszczyk B, Higueruelo A, Wang X, Rossmann M, Perrior TR, Blundell TL, Spring DR, McKenzie G, Abell C, Skidmore J, Venkitaraman AR, Hyvönen M. Stockwell SR, et al. Among authors: venkitaraman ar. J Med Chem. 2024 Sep 12;67(17):15521-15536. doi: 10.1021/acs.jmedchem.4c01165. Epub 2024 Aug 27. J Med Chem. 2024. PMID: 39190548 Free PMC article.
A glycolytic metabolite bypasses "two-hit" tumor suppression by BRCA2.
Kong LR, Gupta K, Wu AJ, Perera D, Ivanyi-Nagy R, Ahmed SM, Tan TZ, Tan SL, Fuddin A, Sundaramoorthy E, Goh GS, Wong RTX, Costa ASH, Oddy C, Wong H, Patro CPK, Kho YS, Huang XZ, Choo J, Shehata M, Lee SC, Goh BC, Frezza C, Pitt JJ, Venkitaraman AR. Kong LR, et al. Among authors: venkitaraman ar. Cell. 2024 Apr 25;187(9):2269-2287.e16. doi: 10.1016/j.cell.2024.03.006. Epub 2024 Apr 11. Cell. 2024. PMID: 38608703 Free article.
Cabergoline as a Novel Strategy for Post-Pregnancy Breast Cancer Prevention in Mice and Human.
García-Sancha N, Corchado-Cobos R, Blanco-Gómez A, Cunillera Puértolas O, Marzo-Castillejo M, Castillo-Lluva S, Alonso-López D, De Las Rivas J, Pozo J, Orfao A, Valero-Juan L, Patino-Alonso C, Perera D, Venkitaraman AR, Mao JH, Chang H, Mendiburu-Eliçabe M, González-García P, Caleiras E, Peset I, Cenador MBG, García-Criado FJ, Pérez-Losada J. García-Sancha N, et al. Among authors: venkitaraman ar. Res Sq [Preprint]. 2024 Feb 5:rs.3.rs-3854490. doi: 10.21203/rs.3.rs-3854490/v1. Res Sq. 2024. PMID: 38405932 Free PMC article. Preprint.
Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia.
Ferrer M, Mourikis N, Davidson EE, Kleeman SO, Zaccaria M, Habel J, Rubino R, Gao Q, Flint TR, Young L, Connell CM, Lukey MJ, Goncalves MD, White EP, Venkitaraman AR, Janowitz T. Ferrer M, et al. Among authors: venkitaraman ar. Cell Metab. 2023 Jul 11;35(7):1147-1162.e7. doi: 10.1016/j.cmet.2023.05.008. Epub 2023 Jun 12. Cell Metab. 2023. PMID: 37311455 Free PMC article.
Domain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities.
Ho TLF, Lee MY, Goh HC, Ng GYN, Lee JJH, Kannan S, Lim YT, Zhao T, Lim EKH, Phua CZJ, Lee YF, Lim RYX, Ng PJH, Yuan J, Chan DKH, Lieske B, Chong CS, Lee KC, Lum J, Cheong WK, Yeoh KG, Tan KK, Sobota RM, Verma CS, Lane DP, Tam WL, Venkitaraman AR. Ho TLF, et al. Among authors: venkitaraman ar. Nat Commun. 2023 Mar 28;14(1):1726. doi: 10.1038/s41467-023-37223-3. Nat Commun. 2023. PMID: 36977662 Free PMC article.
Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia.
Ferrer M, Mourikis N, Davidson EE, Kleeman SO, Zaccaria M, Habel J, Rubino R, Flint TR, Connell CM, Lukey MJ, White EP, Coll AP, Venkitaraman AR, Janowitz T. Ferrer M, et al. Among authors: venkitaraman ar. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.528937. doi: 10.1101/2023.02.17.528937. bioRxiv. 2023. Update in: Cell Metab. 2023 Jul 11;35(7):1147-1162.e7. doi: 10.1016/j.cmet.2023.05.008 PMID: 36824830 Free PMC article. Updated. Preprint.
172 results