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Progression to type 1 diabetes in the DPT-1 and TN07 clinical trials is critically associated with specific residues in HLA-DQA1-B1 heterodimers.
Zhao LP, Papadopoulos GK, Skyler JS, Pugliese A, Parikh HM, Kwok WW, Lybrand TP, Bondinas GP, Moustakas AK, Wang R, Pyo CW, Nelson WC, Geraghty DE, Lernmark Å. Zhao LP, et al. Among authors: moustakas ak. Diabetologia. 2024 Nov;67(11):2481-2493. doi: 10.1007/s00125-024-06274-6. Epub 2024 Oct 1. Diabetologia. 2024. PMID: 39354095 Free PMC article.
HLA Class II (DR, DQ, DP) Genes Were Separately Associated With the Progression From Seroconversion to Onset of Type 1 Diabetes Among Participants in Two Diabetes Prevention Trials (DPT-1 and TN07).
Zhao LP, Papadopoulos GK, Skyler JS, Pugliese A, Parikh HM, Kwok WW, Lybrand TP, Bondinas GP, Moustakas AK, Wang R, Pyo CW, Nelson WC, Geraghty DE, Lernmark Å. Zhao LP, et al. Among authors: moustakas ak. Diabetes Care. 2024 May 1;47(5):826-834. doi: 10.2337/dc23-1947. Diabetes Care. 2024. PMID: 38498185
Eleven Amino Acids of HLA-DRB1 and Fifteen Amino Acids of HLA-DRB3, 4, and 5 Include Potentially Causal Residues Responsible for the Risk of Childhood Type 1 Diabetes.
Zhao LP, Papadopoulos GK, Kwok WW, Xu B, Kong M, Moustakas AK, Bondinas GP, Carlsson A, Elding-Larsson H, Ludvigsson J, Marcus C, Persson M, Samuelsson U, Wang R, Pyo CW, Nelson WC, Geraghty DE, Lernmark Å. Zhao LP, et al. Among authors: moustakas ak. Diabetes. 2019 Aug;68(8):1692-1704. doi: 10.2337/db19-0273. Epub 2019 May 24. Diabetes. 2019. PMID: 31127057 Free PMC article.
Motifs of Three HLA-DQ Amino Acid Residues (α44, β57, β135) Capture Full Association With the Risk of Type 1 Diabetes in DQ2 and DQ8 Children.
Zhao LP, Papadopoulos GK, Kwok WW, Moustakas AK, Bondinas GP, Larsson HE, Ludvigsson J, Marcus C, Samuelsson U, Wang R, Pyo CW, Nelson WC, Geraghty DE, Lernmark Å. Zhao LP, et al. Among authors: moustakas ak. Diabetes. 2020 Jul;69(7):1573-1587. doi: 10.2337/db20-0075. Epub 2020 Apr 3. Diabetes. 2020. PMID: 32245799 Free PMC article.
Next-Generation HLA Sequence Analysis Uncovers Seven HLA-DQ Amino Acid Residues and Six Motifs Resistant to Childhood Type 1 Diabetes.
Zhao LP, Papadopoulos GK, Kwok WW, Moustakas AK, Bondinas GP, Carlsson A, Elding Larsson H, Ludvigsson J, Marcus C, Samuelsson U, Wang R, Pyo CW, Nelson WC, Geraghty DE, Lernmark Å. Zhao LP, et al. Among authors: moustakas ak. Diabetes. 2020 Nov;69(11):2523-2535. doi: 10.2337/db20-0374. Epub 2020 Aug 31. Diabetes. 2020. PMID: 32868339 Free PMC article.
The KAG motif of HLA-DRB1 (β71, β74, β86) predicts seroconversion and development of type 1 diabetes.
Zhao LP, Papadopoulos GK, Lybrand TP, Moustakas AK, Bondinas GP, Carlsson A, Larsson HE, Ludvigsson J, Marcus C, Persson M, Samuelsson U, Wang R, Pyo CW, Nelson WC, Geraghty DE, Rich SS, Lernmark Å; BDD study group. Zhao LP, et al. Among authors: moustakas ak. EBioMedicine. 2021 Jul;69:103431. doi: 10.1016/j.ebiom.2021.103431. Epub 2021 Jun 19. EBioMedicine. 2021. PMID: 34153873 Free PMC article.
43 results