Fullwood NJ - Search Results

1

A novel peptide-based tau aggregation inhibitor as a potential therapeutic for Alzheimer's disease and other tauopathies.

Aggidis A, Devitt G, Zhang Y, Chatterjee S, Townsend D, Fullwood NJ, Ortega ER, Tarutani A, Hasegawa M, Cooper A, Williamson P, Mendoza-Oliva A, Diamond MI, Mudher A, Allsop D. Aggidis A, et al. Among authors: fullwood nj. Alzheimers Dement. 2024 Nov;20(11):7788-7804. doi: 10.1002/alz.14246. Epub 2024 Oct 3. Alzheimers Dement. 2024. PMID: 39360630 Free PMC article.

2

Development of proteolytically stable N-methylated peptide inhibitors of aggregation of the amylin peptide implicated in type 2 diabetes.

Obasse I, Taylor M, Fullwood NJ, Allsop D. Obasse I, et al. Among authors: fullwood nj. Interface Focus. 2017 Dec 6;7(6):20160127. doi: 10.1098/rsfs.2016.0127. Epub 2017 Oct 20. Interface Focus. 2017. PMID: 29147551 Free PMC article.

3

Liposome delivery systems for the treatment of Alzheimer's disease.

Ross C, Taylor M, Fullwood N, Allsop D. Ross C, et al. Int J Nanomedicine. 2018 Dec 12;13:8507-8522. doi: 10.2147/IJN.S183117. eCollection 2018. Int J Nanomedicine. 2018. PMID: 30587974 Free PMC article. Review.

4

Aggregation Kinetics and Filament Structure of a Tau Fragment Are Influenced by the Sulfation Pattern of the Cofactor Heparin.

Townsend D, Fullwood NJ, Yates EA, Middleton DA. Townsend D, et al. Among authors: fullwood nj. Biochemistry. 2020 Oct 20;59(41):4003-4014. doi: 10.1021/acs.biochem.0c00443. Epub 2020 Oct 1. Biochemistry. 2020. PMID: 32954725 Free PMC article.

5

Both the D-(+) and L-(-) enantiomers of nicotine inhibit Abeta aggregation and cytotoxicity.

Moore SA, Huckerby TN, Gibson GL, Fullwood NJ, Turnbull S, Tabner BJ, El-Agnaf OM, Allsop D. Moore SA, et al. Among authors: fullwood nj. Biochemistry. 2004 Jan 27;43(3):819-26. doi: 10.1021/bi035728h. Biochemistry. 2004. PMID: 14730987

6

Retro-inverso peptide inhibitor nanoparticles as potent inhibitors of aggregation of the Alzheimer's Aβ peptide.

Gregori M, Taylor M, Salvati E, Re F, Mancini S, Balducci C, Forloni G, Zambelli V, Sesana S, Michael M, Michail C, Tinker-Mill C, Kolosov O, Sherer M, Harris S, Fullwood NJ, Masserini M, Allsop D. Gregori M, et al. Among authors: fullwood nj. Nanomedicine. 2017 Feb;13(2):723-732. doi: 10.1016/j.nano.2016.10.006. Epub 2016 Oct 19. Nanomedicine. 2017. PMID: 27769888 Free article.

7

Circular Dichroism Spectroscopy Identifies the β-Adrenoceptor Agonist Salbutamol As a Direct Inhibitor of Tau Filament Formation in Vitro.

Townsend DJ, Mala B, Hughes E, Hussain R, Siligardi G, Fullwood NJ, Middleton DA. Townsend DJ, et al. Among authors: fullwood nj. ACS Chem Neurosci. 2020 Jul 15;11(14):2104-2116. doi: 10.1021/acschemneuro.0c00154. Epub 2020 Jul 6. ACS Chem Neurosci. 2020. PMID: 32520518

8

Copper-mediated formation of hydrogen peroxide from the amylin peptide: a novel mechanism for degeneration of islet cells in type-2 diabetes mellitus?

Masad A, Hayes L, Tabner BJ, Turnbull S, Cooper LJ, Fullwood NJ, German MJ, Kametani F, El-Agnaf OM, Allsop D. Masad A, et al. Among authors: fullwood nj. FEBS Lett. 2007 Jul 24;581(18):3489-93. doi: 10.1016/j.febslet.2007.06.061. Epub 2007 Jul 2. FEBS Lett. 2007. PMID: 17617411 Free article.

9

A strategy for designing inhibitors of alpha-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders.

El-Agnaf OM, Paleologou KE, Greer B, Abogrein AM, King JE, Salem SA, Fullwood NJ, Benson FE, Hewitt R, Ford KJ, Martin FL, Harriott P, Cookson MR, Allsop D. El-Agnaf OM, et al. Among authors: fullwood nj. FASEB J. 2004 Aug;18(11):1315-7. doi: 10.1096/fj.03-1346fje. Epub 2004 Jun 4. FASEB J. 2004. PMID: 15180968

10

Hydrogen peroxide is generated during the very early stages of aggregation of the amyloid peptides implicated in Alzheimer disease and familial British dementia.

Tabner BJ, El-Agnaf OM, Turnbull S, German MJ, Paleologou KE, Hayashi Y, Cooper LJ, Fullwood NJ, Allsop D. Tabner BJ, et al. Among authors: fullwood nj. J Biol Chem. 2005 Oct 28;280(43):35789-92. doi: 10.1074/jbc.C500238200. Epub 2005 Sep 1. J Biol Chem. 2005. PMID: 16141213 Free article.

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