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CWHM-974 is a fluphenazine derivative with improved antifungal activity against Candida albicans due to reduced susceptibility to multidrug transporter-mediated resistance mechanisms.
Miron-Ocampo A, Beattie SR, Guin S, Conway T, Meyers MJ, Moye-Rowley WS, Krysan DJ. Miron-Ocampo A, et al. Among authors: meyers mj. Antimicrob Agents Chemother. 2023 Oct 18;67(10):e0056723. doi: 10.1128/aac.00567-23. Epub 2023 Sep 13. Antimicrob Agents Chemother. 2023. PMID: 37702508 Free PMC article.
MEPicides: α,β-unsaturated Fosmidomycin N-Acyl Analogs as Efficient Inhibitors of Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate reductoisomerase.
Wang X, Edwards RL, Ball HS, Heidel KM, Brothers RC, Johnson C, Haymond A, Girma M, Dailey A, Roma JS, Boshoff HI, Osbourn DM, Meyers MJ, Couch RD, Odom John AR, Dowd CS. Wang X, et al. Among authors: meyers mj. ACS Infect Dis. 2023 Jul 14;9(7):1387-1395. doi: 10.1021/acsinfecdis.3c00132. Epub 2023 Jun 13. ACS Infect Dis. 2023. PMID: 37310810 Free PMC article.
Identification of potent and orally efficacious phosphodiesterase inhibitors in Cryptosporidium parvum-infected immunocompromised male mice.
Ajiboye J, Teixeira JE, Gasonoo M, Mattice EB, Korwin-Mihavics B, Miller P, Cameron AC, Stebbins E, Campbell SD, Griggs DW, Spangenberg T, Meyers MJ, Huston CD. Ajiboye J, et al. Among authors: meyers mj. Nat Commun. 2024 Sep 27;15(1):8272. doi: 10.1038/s41467-024-52658-y. Nat Commun. 2024. PMID: 39333545 Free PMC article.
Analogues of the anti-malaria drug mefloquine have broad spectrum antifungal activity and are efficacious in a model of disseminated Candida auris infection.
Guin S, Montoya MC, Wang X, Zarnowski R, Andes DR, Meyers MJ, Williams NS, Krysan DJ. Guin S, et al. Among authors: meyers mj. bioRxiv [Preprint]. 2024 Aug 30:2024.08.29.610379. doi: 10.1101/2024.08.29.610379. bioRxiv. 2024. Update in: Antimicrob Agents Chemother. 2024 Nov 6;68(11):e0130124. doi: 10.1128/aac.01301-24 PMID: 39257751 Free PMC article. Updated. Preprint.
Comparative chemical genomics in Babesia species identifies the alkaline phosphatase PhoD as a determinant of antiparasitic resistance.
Keroack CD, Elsworth B, Tennessen JA, Paul AS, Hua R, Ramirez-Ramirez L, Ye S, Moreira CK, Meyers MJ, Zarringhalam K, Duraisingh MT. Keroack CD, et al. Among authors: meyers mj. Proc Natl Acad Sci U S A. 2024 Feb 27;121(9):e2312987121. doi: 10.1073/pnas.2312987121. Epub 2024 Feb 20. Proc Natl Acad Sci U S A. 2024. PMID: 38377214 Free PMC article.
Targeting CXCR4, VLA-4, and CXCR2 for hematopoietic stem cell mobilization.
Cancilla D, Rettig MP, Karpova D, Thakellapalli H, Singh M, Meyers MJ, Ruminski PG, Christ S, Chendamarai E, Gao F, Gehrs L, Ritchey JK, Prinsen M, DiPersio JF. Cancilla D, et al. Among authors: meyers mj. Blood Adv. 2024 Mar 26;8(6):1379-1383. doi: 10.1182/bloodadvances.2023011653. Blood Adv. 2024. PMID: 38190608 Free PMC article. No abstract available.
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