Walsh I - Search Results

1

Generating and characterizing a comprehensive panel of CHO cells glycosylation mutants for advancing glycobiology and biotechnology research.

Haryadi R, Chan KF, Lin PC, Tan YL, Wan C, Shahreel W, Tay SJ, Nguyen-Khuong T, Walsh I, Song Z. Haryadi R, et al. Among authors: walsh i. Sci Rep. 2024 Oct 4;14(1):23068. doi: 10.1038/s41598-024-73722-z. Sci Rep. 2024. PMID: 39367021 Free PMC article.

2

Enhancing pharmacokinetic and pharmacodynamic properties of recombinant therapeutic proteins by manipulation of sialic acid content.

Chia S, Tay SJ, Song Z, Yang Y, Walsh I, Pang KT. Chia S, et al. Among authors: walsh i. Biomed Pharmacother. 2023 Jul;163:114757. doi: 10.1016/j.biopha.2023.114757. Epub 2023 Apr 21. Biomed Pharmacother. 2023. PMID: 37087980 Free article. Review.

3

Optimizing effector functions of monoclonal antibodies via tailored N-glycan engineering using a dual landing pad CHO targeted integration platform.

Nguyen NTB, Leung HW, Pang KT, Tay SJ, Walsh I, Choo ABH, Yang Y. Nguyen NTB, et al. Among authors: walsh i. Sci Rep. 2023 Sep 20;13(1):15620. doi: 10.1038/s41598-023-42925-1. Sci Rep. 2023. PMID: 37731040 Free PMC article.

4

Antibody glycan quality predicted from CHO cell culture media markers and machine learning.

Lakshmanan M, Chia S, Pang KT, Sim LC, Teo G, Mak SY, Chen S, Lim HL, Lee AP, Bin Mahfut F, Ng SK, Yang Y, Soh A, Tan AH, Choo A, Ho YS, Nguyen-Khuong T, Walsh I. Lakshmanan M, et al. Among authors: walsh i. Comput Struct Biotechnol J. 2024 Jun 1;23:2497-2506. doi: 10.1016/j.csbj.2024.05.046. eCollection 2024 Dec. Comput Struct Biotechnol J. 2024. PMID: 38966680 Free PMC article.

5

Thermal and pH stress dictate distinct mechanisms of monoclonal antibody aggregation.

Meng HK, Pang KT, Wan C, Zheng ZY, Beiying Q, Yang Y, Zhang W, Ho YS, Walsh I, Chia S. Meng HK, et al. Among authors: walsh i. Int J Biol Macromol. 2024 Oct 18;282(Pt 2):136601. doi: 10.1016/j.ijbiomac.2024.136601. Online ahead of print. Int J Biol Macromol. 2024. PMID: 39427803

6

Genome-Scale Modeling of CHO Cells Unravel the Critical Role of Asparagine in Cell Culture Feed Media.

Pang KT, Hong YF, Shozui F, Furomitsu S, Myint M, Ho YS, Silberberg YR, Walsh I, Lakshmanan M. Pang KT, et al. Among authors: walsh i. Biotechnol J. 2024 Nov;19(11):e202400072. doi: 10.1002/biot.202400072. Biotechnol J. 2024. PMID: 39513375

7

Biomass specific perfusion rate as a control lever for the continuous manufacturing of biosimilar monoclonal antibodies from CHO cell cultures.

Leong J, Tang WQ, Chng J, Ler WX, Manan NA, Sim LC, Zheng ZY, Zhang W, Walsh I, Zijlstra G, Pennings M, Ng SK. Leong J, et al. Among authors: walsh i. Biotechnol J. 2024 Jul;19(7):e2400092. doi: 10.1002/biot.202400092. Biotechnol J. 2024. PMID: 38987222

8

Insight into muscle stem cell regeneration and mechanobiology.

Pang KT, Loo LSW, Chia S, Ong FYT, Yu H, Walsh I. Pang KT, et al. Among authors: walsh i. Stem Cell Res Ther. 2023 May 12;14(1):129. doi: 10.1186/s13287-023-03363-y. Stem Cell Res Ther. 2023. PMID: 37173707 Free PMC article. Review.

9

Understanding and controlling the molecular mechanisms of protein aggregation in mAb therapeutics.

Pang KT, Yang YS, Zhang W, Ho YS, Sormanni P, Michaels TCT, Walsh I, Chia S. Pang KT, et al. Among authors: walsh i. Biotechnol Adv. 2023 Oct;67:108192. doi: 10.1016/j.biotechadv.2023.108192. Epub 2023 Jun 7. Biotechnol Adv. 2023. PMID: 37290583 Free article. Review.

10

Effectiveness of interventions for informal caregivers of people with end-stage chronic illness: a systematic review.

McGuigan K, Laurente G, Christie A, Carswell C, Moran C, Yaqoob MM, Bolton S, Mullan R, Rej S, Gilbert P, McKeaveney C, McVeigh C, Tierney C, Reid J, Walsh I, Forbes T, Noble H. McGuigan K, et al. Among authors: walsh i. Syst Rev. 2024 Sep 28;13(1):245. doi: 10.1186/s13643-024-02641-x. Syst Rev. 2024. PMID: 39342397 Free PMC article.

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