Lee JH - Search Results

1

Discovery of a selective cytochrome P450 4A inhibitor for the treatment of metabolic dysfunction-associated fatty liver disease.

Lee M, Son MJ, Hong SH, Ryu JS, Min JH, Lee DE, Lee JH, Kim ND, Park SY, Kim D, Joo J, Kwak J, Kim KH, Lee YH, Keum BR, Song HS, Jung Y, Kim KS, Kim GH. Lee M, et al. Among authors: lee yh, lee jh, lee de. Clin Transl Med. 2024 Oct;14(10):e1816. doi: 10.1002/ctm2.1816. Clin Transl Med. 2024. PMID: 39367660 Free PMC article. No abstract available.

2

A Novel Protein-Protein Interaction between RSK3 and IκBα and a New Binding Inhibitor That Suppresses Breast Cancer Tumorigenesis.

Yoon HS, Choi SH, Park JH, Min JY, Hyon JY, Yang Y, Jung S, Kim JY, Kim ND, Lee JH, Han EH, Chi SG, Chung YH. Yoon HS, et al. Among authors: lee jh. Cancers (Basel). 2021 Jun 14;13(12):2973. doi: 10.3390/cancers13122973. Cancers (Basel). 2021. PMID: 34198590 Free PMC article.

3

Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1.

Jung S, Yoon NG, Yang S, Kim D, Lee WS, Hong KB, Lee C, Kang BH, Lee JH, Kang S. Jung S, et al. Among authors: lee ws, lee jh, lee c. Bioorg Med Chem Lett. 2020 Jan 15;30(2):126809. doi: 10.1016/j.bmcl.2019.126809. Epub 2019 Nov 11. Bioorg Med Chem Lett. 2020. PMID: 31839539

4

Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models.

Kim D, Kim SY, Kim D, Yoon NG, Yun J, Hong KB, Lee C, Lee JH, Kang BH, Kang S. Kim D, et al. Among authors: lee jh, lee c. Bioorg Chem. 2020 Aug;101:103901. doi: 10.1016/j.bioorg.2020.103901. Epub 2020 Jun 15. Bioorg Chem. 2020. PMID: 32590225

5

Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site.

Yoon NG, Lee H, Kim SY, Hu S, Kim D, Yang S, Hong KB, Lee JH, Kang S, Kim BG, Myung K, Lee C, Kang BH. Yoon NG, et al. Among authors: lee h, lee jh, lee c. J Am Chem Soc. 2021 Dec 1;143(47):19684-19696. doi: 10.1021/jacs.1c07099. Epub 2021 Nov 10. J Am Chem Soc. 2021. PMID: 34758612

6

Modulation of Amyloid and Tau Aggregation to Alleviate Cognitive Impairment in a Transgenic Mouse Model of Alzheimer's Disease.

Park S, Shin J, Kim K, Kim D, Lee WS, Lee J, Cho I, Park IW, Yoon S, Lee S, Kim HY, Lee JH, Hong KB, Kim Y. Park S, et al. Among authors: lee j, lee ws, lee jh, lee s. ACS Pharmacol Transl Sci. 2024 Jun 26;7(9):2650-2661. doi: 10.1021/acsptsci.4c00006. eCollection 2024 Sep 13. ACS Pharmacol Transl Sci. 2024. PMID: 39296253

7

CF₃-Substituted Mollugin 2-(4-Morpholinyl)-ethyl ester as a Potential Anti-inflammatory Agent with Improved Aqueous Solubility and Metabolic Stability.

Hong KB, Kim D, Kim BK, Woo SY, Lee JH, Han SH, Bae GU, Kang S. Hong KB, et al. Among authors: lee jh. Molecules. 2018 Aug 14;23(8):2030. doi: 10.3390/molecules23082030. Molecules. 2018. PMID: 30110934 Free PMC article.

8

Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors.

Park HK, Jeong H, Ko E, Lee G, Lee JE, Lee SK, Lee AJ, Im JY, Hu S, Kim SH, Lee JH, Lee C, Kang S, Kang BH. Park HK, et al. Among authors: lee g, lee aj, lee sk, lee je, lee jh, lee c. J Med Chem. 2017 Sep 14;60(17):7569-7578. doi: 10.1021/acs.jmedchem.7b00978. Epub 2017 Aug 30. J Med Chem. 2017. PMID: 28816449

9

Novel Inhibitor of Mixed-Lineage Kinase Domain-Like Protein: The Antifibrotic Effects of a Necroptosis Antagonist.

Oh JH, Park S, Hong E, Choi MA, Kwon YM, Park JW, Lee AH, Park GR, Kim HY, Lee SM, Lee JY, Bae SH, Lee JH, Lee JY, Jun DW. Oh JH, et al. Among authors: lee ah, lee sm, lee jy, lee jh. ACS Pharmacol Transl Sci. 2023 Sep 11;6(10):1471-1479. doi: 10.1021/acsptsci.3c00131. eCollection 2023 Oct 13. ACS Pharmacol Transl Sci. 2023. PMID: 37854622 Free PMC article.

10

Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity.

Yang S, Yoon NG, Kim D, Park E, Kim SY, Lee JH, Lee C, Kang BH, Kang S. Yang S, et al. Among authors: lee jh, lee c. ACS Med Chem Lett. 2021 Jun 16;12(7):1173-1180. doi: 10.1021/acsmedchemlett.1c00213. eCollection 2021 Jul 8. ACS Med Chem Lett. 2021. PMID: 34267888 Free PMC article.

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