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Sustained effect of prasinezumab on Parkinson's disease motor progression in the open-label extension of the PASADENA trial.
Pagano G, Monnet A, Reyes A, Ribba B, Svoboda H, Kustermann T, Simuni T, Postuma RB, Pavese N, Stocchi F, Brockmann K, Smigorski K, Gerbaldo V, Fontoura P, Doody R, Kerchner GA, Brundin P, Marek K, Bonni A, Nikolcheva T; PASADENA Investigators; Prasinezumab Study Group. Pagano G, et al. Among authors: brundin p. Nat Med. 2024 Oct 8. doi: 10.1038/s41591-024-03270-6. Online ahead of print. Nat Med. 2024. PMID: 39379705
Prasinezumab slows motor progression in rapidly progressing early-stage Parkinson's disease.
Pagano G, Taylor KI, Anzures Cabrera J, Simuni T, Marek K, Postuma RB, Pavese N, Stocchi F, Brockmann K, Svoboda H, Trundell D, Monnet A, Doody R, Fontoura P, Kerchner GA, Brundin P, Nikolcheva T, Bonni A; PASADENA Investigators; Prasinezumab Study Group. Pagano G, et al. Among authors: brundin p. Nat Med. 2024 Apr;30(4):1096-1103. doi: 10.1038/s41591-024-02886-y. Epub 2024 Apr 15. Nat Med. 2024. PMID: 38622249 Free PMC article.
Twelve Years of Drug Prioritization to Help Accelerate Disease Modification Trials in Parkinson's Disease: The International Linked Clinical Trials Initiative.
Wyse RK, Isaacs T, Barker RA, Cookson MR, Dawson TM, Devos D, Dexter DT, Duffen J, Federoff H, Fiske B, Foltynie T, Fox S, Greenamyre JT, Kieburtz K, Kordower JH, Krainc D, Matthews H, Moore DJ, Mursaleen L, Schwarzschild MA, Stott SRW, Sulzer D, Svenningsson P, Tanner CM, Carroll C, Simon DK, Brundin P. Wyse RK, et al. Among authors: brundin p. J Parkinsons Dis. 2024;14(4):657-666. doi: 10.3233/JPD-230363. J Parkinsons Dis. 2024. PMID: 38578902 Free PMC article. Review.
Specific immune modulation of experimental colitis drives enteric alpha-synuclein accumulation and triggers age-related Parkinson-like brain pathology.
Grathwohl S, Quansah E, Maroof N, Steiner JA, Spycher L, Benmansour F, Duran-Pacheco G, Siebourg-Polster J, Oroszlan-Szovik K, Remy H, Haenggi M, Stawiski M, Selhausen M, Mailver P, Wolfert A, Emrich T, Madaj Z, Su A, Escobar Galvis ML, Mueller C, Herrmann A, Brundin P, Britschgi M. Grathwohl S, et al. Among authors: brundin p. Free Neuropathol. 2021 May 18;2:2-13. doi: 10.17879/freeneuropathology-2021-3326. eCollection 2021 Jan. Free Neuropathol. 2021. PMID: 37284635 Free PMC article.
Urinary tract infections trigger synucleinopathy via the innate immune response.
Peelaerts W, Mercado G, George S, Villumsen M, Kasen A, Aguileta M, Linstow C, Sutter AB, Kuhn E, Stetzik L, Sheridan R, Bergkvist L, Meyerdirk L, Lindqvist A, Gavis MLE, Van den Haute C, Hultgren SJ, Baekelandt V, Pospisilik JA, Brudek T, Aznar S, Steiner JA, Henderson MX, Brundin L, Ivanova MI, Hannan TJ, Brundin P. Peelaerts W, et al. Among authors: brundin p. Acta Neuropathol. 2023 May;145(5):541-559. doi: 10.1007/s00401-023-02562-4. Epub 2023 Mar 30. Acta Neuropathol. 2023. PMID: 36991261 Free PMC article.
Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy.
Parmasad JA, Ricke KM, Nguyen B, Stykel MG, Buchner-Duby B, Bruce A, Geertsma HM, Lian E, Lengacher NA, Callaghan SM, Joselin A, Tomlinson JJ, Schlossmacher MG, Stanford WL, Ma J, Brundin P, Ryan SD, Rousseaux MWC. Parmasad JA, et al. Among authors: brundin p. Cell Death Dis. 2024 Apr 4;15(4):246. doi: 10.1038/s41419-024-06534-8. Cell Death Dis. 2024. PMID: 38575601 Free PMC article.
Air pollution nanoparticle and alpha-synuclein fibrils synergistically decrease glutamate receptor A1, depending upon nPM batch activity.
Zhang H, D'Agostino C, Tulisiak C, Thorwald MA, Bergkvist L, Lindquist A, Meyerdirk L, Schulz E, Becker K, Steiner JA, Cacciottolo M, Kwatra M, Rey NL, Escobar Galvis ML, Ma J, Sioutas C, Morgan TE, Finch CE, Brundin P. Zhang H, et al. Among authors: brundin p. Heliyon. 2023 Apr 19;9(4):e15622. doi: 10.1016/j.heliyon.2023.e15622. eCollection 2023 Apr. Heliyon. 2023. PMID: 37128335 Free PMC article.
440 results