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Impaired 11β-hydroxysteroid dehydrogenase type 2 activity in kidney disease disrupts 11-oxygenated androgen biosynthesis.
Tomkins M, McDonnell T, Cussen L, Sagmeister MS, Oestlund I, Shaheen F, Harper L, Hardy RS, Taylor AE, Gilligan LC, Arlt W, McIlroy M, de Freitas D, Conlon P, Magee C, Denton M, O'Seaghdha C, Snoep JL, Storbeck KH, Sherlock M, O'Reilly MW. Tomkins M, et al. Among authors: sagmeister ms. J Clin Endocrinol Metab. 2024 Oct 9:dgae714. doi: 10.1210/clinem/dgae714. Online ahead of print. J Clin Endocrinol Metab. 2024. PMID: 39382395
Glucocorticoid activation by 11β-hydroxysteroid dehydrogenase enzymes in relation to inflammation and glycaemic control in chronic kidney disease: A cross-sectional study.
Sagmeister MS, Taylor AE, Fenton A, Wall NA, Chanouzas D, Nightingale PG, Ferro CJ, Arlt W, Cockwell P, Hardy RS, Harper L. Sagmeister MS, et al. Clin Endocrinol (Oxf). 2019 Jan;90(1):241-249. doi: 10.1111/cen.13889. Epub 2018 Nov 15. Clin Endocrinol (Oxf). 2019. PMID: 30358903 Free PMC article.
11βHSD1 Inhibition with AZD4017 Improves Lipid Profiles and Lean Muscle Mass in Idiopathic Intracranial Hypertension.
Hardy RS, Botfield H, Markey K, Mitchell JL, Alimajstorovic Z, Westgate CSJ, Sagmeister M, Fairclough RJ, Ottridge RS, Yiangou A, Storbeck KH, Taylor AE, Gilligan LC, Arlt W, Stewart PM, Tomlinson JW, Mollan SP, Lavery GG, Sinclair AJ. Hardy RS, et al. J Clin Endocrinol Metab. 2021 Jan 1;106(1):174-187. doi: 10.1210/clinem/dgaa766. J Clin Endocrinol Metab. 2021. PMID: 33098644 Free PMC article. Clinical Trial.
Inflammation dynamically regulates steroid hormone metabolism and action within macrophages in rheumatoid arthritis.
Martin CS, Crastin A, Sagmeister MS, Kalirai MS, Turner JD, MacDonald L, Kurowska-Stolarska M, Scheel-Toellner D, Taylor AE, Gilligan LC, Storbeck K, Price M, Gorvin CM, A F, Mahida R, Clark AR, Jones SW, Raza K, Hewison M, Hardy RS. Martin CS, et al. Among authors: sagmeister ms. J Autoimmun. 2024 Jul;147:103263. doi: 10.1016/j.jaut.2024.103263. Epub 2024 Jun 8. J Autoimmun. 2024. PMID: 38851089 Free article.
Subclinical Reactivation of Cytomegalovirus Drives CD4+CD28null T-Cell Expansion and Impaired Immune Response to Pneumococcal Vaccination in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Chanouzas D, Sagmeister M, Faustini S, Nightingale P, Richter A, Ferro CJ, Morgan MD, Moss P, Harper L. Chanouzas D, et al. J Infect Dis. 2019 Jan 7;219(2):234-244. doi: 10.1093/infdis/jiy493. J Infect Dis. 2019. PMID: 30102389 Free PMC article. Clinical Trial.
13 results