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Histone modifications of circulating nucleosomes are associated with changes in cell-free DNA fragmentation patterns.
Bai J, Jiang P, Ji L, Lam WKJ, Zhou Q, Ma ML, Ding SC, Ramakrishnan S, Wan CW, Yang TC, Yukawa M, Chan RWY, Qiao R, Yu SCY, Choy LYL, Shi Y, Wang Z, Tam THC, Law MF, Wong RSM, Wong J, Chan SL, Wong GLH, Wong VWS, Chan KCA, Lo YMD. Bai J, et al. Among authors: choy lyl. Proc Natl Acad Sci U S A. 2024 Oct 15;121(42):e2404058121. doi: 10.1073/pnas.2404058121. Epub 2024 Oct 9. Proc Natl Acad Sci U S A. 2024. PMID: 39382996 Free PMC article.
Analysis of a cell-free DNA-based cancer screening cohort links fragmentomic profiles, nuclease levels, and plasma DNA concentrations.
Malki Y, Kang G, Lam WKJ, Zhou Q, Cheng SH, Cheung PPH, Bai J, Chan ML, Lee CT, Peng W, Zhang Y, Gai W, Wong WSW, Ma MJL, Li W, Xu X, Gao Z, Tse IOL, Shang H, Choy LYL, Jiang P, Chan KCA, Lo YMD. Malki Y, et al. Among authors: choy lyl. Genome Res. 2024 Nov 27:gr.279667.124. doi: 10.1101/gr.279667.124. Online ahead of print. Genome Res. 2024. PMID: 39603706 Free article.