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Page 1
Targeting the MAtrix REgulating MOtif abolishes several hallmarks of cancer, triggering antitumor immunity.
Li C, Kaur A, Pavlidaki A, Spenlé C, Rajnpreht I, Donnadieu E, Salomé N, Molitor A, Carapito R, Wack F, Erne W, Lefebvre O, Averous G, Mitrentsi I, Loustau T, Orend G. Li C, et al. Among authors: erne w. Proc Natl Acad Sci U S A. 2024 Oct 15;121(42):e2404485121. doi: 10.1073/pnas.2404485121. Epub 2024 Oct 9. Proc Natl Acad Sci U S A. 2024. PMID: 39382998
Modulating tenascin-C functions by targeting the MAtrix REgulating MOtif, "MAREMO".
Loustau T, Abou-Faycal C, Erne W, Zur Wiesch PA, Ksouri A, Imhof T, Mörgelin M, Li C, Mathieu M, Salomé N, Crémel G, Dhaouadi S, Bouhaouala-Zahar B, Koch M, Orend G. Loustau T, et al. Among authors: erne w. Matrix Biol. 2022 Apr;108:20-38. doi: 10.1016/j.matbio.2022.02.007. Epub 2022 Feb 26. Matrix Biol. 2022. PMID: 35227929
Tenascin-C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression.
Murdamoothoo D, Sun Z, Yilmaz A, Riegel G, Abou-Faycal C, Deligne C, Velazquez-Quesada I, Erne W, Nascimento M, Mörgelin M, Cremel G, Paul N, Carapito R, Veber R, Dumortier H, Yuan J, Midwood KS, Loustau T, Orend G. Murdamoothoo D, et al. Among authors: erne w. EMBO Mol Med. 2021 Jun 7;13(6):e13270. doi: 10.15252/emmm.202013270. Epub 2021 May 14. EMBO Mol Med. 2021. PMID: 33988305 Free PMC article.
Novel Human Tenascin-C Function-Blocking Camel Single Domain Nanobodies.
Dhaouadi S, Ben Abderrazek R, Loustau T, Abou-Faycal C, Ksouri A, Erne W, Murdamoothoo D, Mörgelin M, Kungl A, Jung A, Ledrappier S, Benlasfar Z, Bichet S, Chiquet-Ehrismann R, Hendaoui I, Orend G, Bouhaouala-Zahar B. Dhaouadi S, et al. Among authors: erne w. Front Immunol. 2021 Mar 15;12:635166. doi: 10.3389/fimmu.2021.635166. eCollection 2021. Front Immunol. 2021. PMID: 33790905 Free PMC article.
Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma.
Spenlé C, Loustau T, Murdamoothoo D, Erne W, Beghelli-de la Forest Divonne S, Veber R, Petti L, Bourdely P, Mörgelin M, Brauchle EM, Cremel G, Randrianarisoa V, Camara A, Rekima S, Schaub S, Nouhen K, Imhof T, Hansen U, Paul N, Carapito R, Pythoud N, Hirschler A, Carapito C, Dumortier H, Mueller CG, Koch M, Schenke-Layland K, Kon S, Sudaka A, Anjuère F, Van Obberghen-Schilling E, Orend G. Spenlé C, et al. Among authors: erne w. Cancer Immunol Res. 2020 Sep;8(9):1122-1138. doi: 10.1158/2326-6066.CIR-20-0074. Epub 2020 Jul 14. Cancer Immunol Res. 2020. PMID: 32665262 Free article.
Generation and characterization of dromedary Tenascin-C and Tenascin-W specific antibodies.
Dhaouadi S, Murdamoothoo D, Tounsi A, Erne W, Benabderrazek R, Benlasfar Z, Hendaoui L, Chiquet-Ehrismann R, Boubaker S, Orend G, Hendaoui I, Bouhaouala-Zahar B. Dhaouadi S, et al. Among authors: erne w. Biochem Biophys Res Commun. 2020 Sep 17;530(2):471-478. doi: 10.1016/j.bbrc.2020.05.077. Epub 2020 Jun 24. Biochem Biophys Res Commun. 2020. PMID: 32593416
Matrix-Targeting Immunotherapy Controls Tumor Growth and Spread by Switching Macrophage Phenotype.
Deligne C, Murdamoothoo D, Gammage AN, Gschwandtner M, Erne W, Loustau T, Marzeda AM, Carapito R, Paul N, Velazquez-Quesada I, Mazzier I, Sun Z, Orend G, Midwood KS. Deligne C, et al. Among authors: erne w. Cancer Immunol Res. 2020 Mar;8(3):368-382. doi: 10.1158/2326-6066.CIR-19-0276. Epub 2020 Jan 15. Cancer Immunol Res. 2020. PMID: 31941671 Free PMC article.
Tenascin-C increases lung metastasis by impacting blood vessel invasions.
Sun Z, Velázquez-Quesada I, Murdamoothoo D, Ahowesso C, Yilmaz A, Spenlé C, Averous G, Erne W, Oberndorfer F, Oszwald A, Kain R, Bourdon C, Mangin P, Deligne C, Midwood K, Abou-Faycal C, Lefebvre O, Klein A, van der Heyden M, Chenard MP, Christofori G, Mathelin C, Loustau T, Hussenet T, Orend G. Sun Z, et al. Among authors: erne w. Matrix Biol. 2019 Oct;83:26-47. doi: 10.1016/j.matbio.2019.07.001. Epub 2019 Jul 6. Matrix Biol. 2019. PMID: 31288084 Free article.