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Targeting the MAtrix REgulating MOtif abolishes several hallmarks of cancer, triggering antitumor immunity.
Li C, Kaur A, Pavlidaki A, Spenlé C, Rajnpreht I, Donnadieu E, Salomé N, Molitor A, Carapito R, Wack F, Erne W, Lefebvre O, Averous G, Mitrentsi I, Loustau T, Orend G. Li C, et al. Among authors: lefebvre o. Proc Natl Acad Sci U S A. 2024 Oct 15;121(42):e2404485121. doi: 10.1073/pnas.2404485121. Epub 2024 Oct 9. Proc Natl Acad Sci U S A. 2024. PMID: 39382998
Tenascin-C increases lung metastasis by impacting blood vessel invasions.
Sun Z, Velázquez-Quesada I, Murdamoothoo D, Ahowesso C, Yilmaz A, Spenlé C, Averous G, Erne W, Oberndorfer F, Oszwald A, Kain R, Bourdon C, Mangin P, Deligne C, Midwood K, Abou-Faycal C, Lefebvre O, Klein A, van der Heyden M, Chenard MP, Christofori G, Mathelin C, Loustau T, Hussenet T, Orend G. Sun Z, et al. Among authors: lefebvre o. Matrix Biol. 2019 Oct;83:26-47. doi: 10.1016/j.matbio.2019.07.001. Epub 2019 Jul 6. Matrix Biol. 2019. PMID: 31288084 Free article.
Role of laminins in physiological and pathological angiogenesis.
Simon-Assmann P, Orend G, Mammadova-Bach E, Spenlé C, Lefebvre O. Simon-Assmann P, et al. Among authors: lefebvre o. Int J Dev Biol. 2011;55(4-5):455-65. doi: 10.1387/ijdb.103223ps. Int J Dev Biol. 2011. PMID: 21858771 Free article. Review.
Tenascin-C downregulates wnt inhibitor dickkopf-1, promoting tumorigenesis in a neuroendocrine tumor model.
Saupe F, Schwenzer A, Jia Y, Gasser I, Spenlé C, Langlois B, Kammerer M, Lefebvre O, Hlushchuk R, Rupp T, Marko M, van der Heyden M, Cremel G, Arnold C, Klein A, Simon-Assmann P, Djonov V, Neuville-Méchine A, Esposito I, Slotta-Huspenina J, Janssen KP, de Wever O, Christofori G, Hussenet T, Orend G. Saupe F, et al. Among authors: lefebvre o. Cell Rep. 2013 Oct 31;5(2):482-92. doi: 10.1016/j.celrep.2013.09.014. Epub 2013 Oct 17. Cell Rep. 2013. PMID: 24139798 Free article.
Platelets favor the outgrowth of established metastases.
Garcia-Leon MJ, Liboni C, Mittelheisser V, Bochler L, Follain G, Mouriaux C, Busnelli I, Larnicol A, Colin F, Peralta M, Osmani N, Gensbittel V, Bourdon C, Samaniego R, Pichot A, Paul N, Molitor A, Carapito R, Jandrot-Perrus M, Lefebvre O, Mangin PH, Goetz JG. Garcia-Leon MJ, et al. Among authors: lefebvre o. Nat Commun. 2024 May 13;15(1):3297. doi: 10.1038/s41467-024-47516-w. Nat Commun. 2024. PMID: 38740748 Free PMC article.
Tenascin-C Orchestrates Glioblastoma Angiogenesis by Modulation of Pro- and Anti-angiogenic Signaling.
Rupp T, Langlois B, Koczorowska MM, Radwanska A, Sun Z, Hussenet T, Lefebvre O, Murdamoothoo D, Arnold C, Klein A, Biniossek ML, Hyenne V, Naudin E, Velazquez-Quesada I, Schilling O, Van Obberghen-Schilling E, Orend G. Rupp T, et al. Among authors: lefebvre o. Cell Rep. 2016 Dec 6;17(10):2607-2619. doi: 10.1016/j.celrep.2016.11.012. Cell Rep. 2016. PMID: 27926865 Free article.
Dysregulation of laminins in intestinal inflammation.
Spenlé C, Hussenet T, Lacroute J, Lefebvre O, Kedinger M, Orend G, Simon-Assmann P. Spenlé C, et al. Among authors: lefebvre o. Pathol Biol (Paris). 2012 Feb;60(1):41-7. doi: 10.1016/j.patbio.2011.10.005. Epub 2011 Nov 17. Pathol Biol (Paris). 2012. PMID: 22100883 Review.
157 results