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Page 1
Targeting the MAtrix REgulating MOtif abolishes several hallmarks of cancer, triggering antitumor immunity.
Li C, Kaur A, Pavlidaki A, Spenlé C, Rajnpreht I, Donnadieu E, Salomé N, Molitor A, Carapito R, Wack F, Erne W, Lefebvre O, Averous G, Mitrentsi I, Loustau T, Orend G. Li C, et al. Among authors: orend g. Proc Natl Acad Sci U S A. 2024 Oct 15;121(42):e2404485121. doi: 10.1073/pnas.2404485121. Epub 2024 Oct 9. Proc Natl Acad Sci U S A. 2024. PMID: 39382998
Modulating tenascin-C functions by targeting the MAtrix REgulating MOtif, "MAREMO".
Loustau T, Abou-Faycal C, Erne W, Zur Wiesch PA, Ksouri A, Imhof T, Mörgelin M, Li C, Mathieu M, Salomé N, Crémel G, Dhaouadi S, Bouhaouala-Zahar B, Koch M, Orend G. Loustau T, et al. Among authors: orend g. Matrix Biol. 2022 Apr;108:20-38. doi: 10.1016/j.matbio.2022.02.007. Epub 2022 Feb 26. Matrix Biol. 2022. PMID: 35227929
Tenascin-C increases lung metastasis by impacting blood vessel invasions.
Sun Z, Velázquez-Quesada I, Murdamoothoo D, Ahowesso C, Yilmaz A, Spenlé C, Averous G, Erne W, Oberndorfer F, Oszwald A, Kain R, Bourdon C, Mangin P, Deligne C, Midwood K, Abou-Faycal C, Lefebvre O, Klein A, van der Heyden M, Chenard MP, Christofori G, Mathelin C, Loustau T, Hussenet T, Orend G. Sun Z, et al. Among authors: orend g. Matrix Biol. 2019 Oct;83:26-47. doi: 10.1016/j.matbio.2019.07.001. Epub 2019 Jul 6. Matrix Biol. 2019. PMID: 31288084 Free article.
Matrix-Targeting Immunotherapy Controls Tumor Growth and Spread by Switching Macrophage Phenotype.
Deligne C, Murdamoothoo D, Gammage AN, Gschwandtner M, Erne W, Loustau T, Marzeda AM, Carapito R, Paul N, Velazquez-Quesada I, Mazzier I, Sun Z, Orend G, Midwood KS. Deligne C, et al. Among authors: orend g. Cancer Immunol Res. 2020 Mar;8(3):368-382. doi: 10.1158/2326-6066.CIR-19-0276. Epub 2020 Jan 15. Cancer Immunol Res. 2020. PMID: 31941671 Free PMC article.
Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma.
Spenlé C, Loustau T, Murdamoothoo D, Erne W, Beghelli-de la Forest Divonne S, Veber R, Petti L, Bourdely P, Mörgelin M, Brauchle EM, Cremel G, Randrianarisoa V, Camara A, Rekima S, Schaub S, Nouhen K, Imhof T, Hansen U, Paul N, Carapito R, Pythoud N, Hirschler A, Carapito C, Dumortier H, Mueller CG, Koch M, Schenke-Layland K, Kon S, Sudaka A, Anjuère F, Van Obberghen-Schilling E, Orend G. Spenlé C, et al. Among authors: orend g. Cancer Immunol Res. 2020 Sep;8(9):1122-1138. doi: 10.1158/2326-6066.CIR-20-0074. Epub 2020 Jul 14. Cancer Immunol Res. 2020. PMID: 32665262 Free article.
Tenascin-C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression.
Murdamoothoo D, Sun Z, Yilmaz A, Riegel G, Abou-Faycal C, Deligne C, Velazquez-Quesada I, Erne W, Nascimento M, Mörgelin M, Cremel G, Paul N, Carapito R, Veber R, Dumortier H, Yuan J, Midwood KS, Loustau T, Orend G. Murdamoothoo D, et al. Among authors: orend g. EMBO Mol Med. 2021 Jun 7;13(6):e13270. doi: 10.15252/emmm.202013270. Epub 2021 May 14. EMBO Mol Med. 2021. PMID: 33988305 Free PMC article.
Impact of Tenascin-C on Radiotherapy in a Novel Syngeneic Oral Squamous Cell Carcinoma Model With Spontaneous Dissemination to the Lymph Nodes.
Spenlé C, Loustau T, Burckel H, Riegel G, Abou Faycal C, Li C, Yilmaz A, Petti L, Steinbach F, Ahowesso C, Jost C, Paul N, Carapito R, Noël G, Anjuère F, Salomé N, Orend G. Spenlé C, et al. Among authors: orend g. Front Immunol. 2021 Jul 5;12:636108. doi: 10.3389/fimmu.2021.636108. eCollection 2021. Front Immunol. 2021. PMID: 34290694 Free PMC article.
Advances on the roles of tenascin-C in cancer.
Yilmaz A, Loustau T, Salomé N, Poilil Surendran S, Li C, Tucker RP, Izzi V, Lamba R, Koch M, Orend G. Yilmaz A, et al. Among authors: orend g. J Cell Sci. 2022 Sep 15;135(18):jcs260244. doi: 10.1242/jcs.260244. Epub 2022 Sep 14. J Cell Sci. 2022. PMID: 36102918 Free PMC article.
Investigating Chemokine-Matrix Networks in Breast Cancer: Tenascin-C Sets the Tone for CCL2.
Gschwandtner M, Gammage AN, Deligne C, Mies LFM, Domaingo A, Murdamoothoo D, Loustau T, Schwenzer A, Derler R, Carapito R, Koch M, Mörgelin M, Orend G, Kungl AJ, Midwood KS. Gschwandtner M, et al. Among authors: orend g. Int J Mol Sci. 2023 May 6;24(9):8365. doi: 10.3390/ijms24098365. Int J Mol Sci. 2023. PMID: 37176074 Free PMC article.
81 results