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Interactions of hydrolyzed β-lactams with the L1 metallo-β-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products.
Hinchliffe P, Calvopiña K, Rabe P, Mojica MF, Schofield CJ, Dmitrienko GI, Bonomo RA, Vila AJ, Spencer J. Hinchliffe P, et al. Among authors: mojica mf. J Biol Chem. 2024 Oct;300(10):107819. doi: 10.1016/j.jbc.2024.107819. Epub 2024 Oct 9. J Biol Chem. 2024. PMID: 39383701 Free PMC article. No abstract available.
First report of KPC variants conferring ceftazidime-avibactam resistance in Colombia: introducing KPC-197.
De la Cadena E, Mojica MF, Rojas LJ, Castro BE, García-Betancur JC, Marshall SH, Restrepo N, Castro-Caro NP, Fonseca-Carrillo M, Pallares C, Bonomo RA, Villegas MV. De la Cadena E, et al. Among authors: mojica mf. Microbiol Spectr. 2024 Jun 4;12(6):e0410523. doi: 10.1128/spectrum.04105-23. Epub 2024 May 3. Microbiol Spectr. 2024. PMID: 38700337 Free PMC article.
Rational Design of Benzobisheterocycle Metallo-β-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes.
Villamil V, Rossi MA, Mojica MF, Hinchliffe P, Martínez V, Castillo V, Saiz C, Banchio C, Macías MA, Spencer J, Bonomo RA, Vila A, Moreno DM, Mahler G. Villamil V, et al. Among authors: mojica mf. J Med Chem. 2024 Mar 14;67(5):3795-3812. doi: 10.1021/acs.jmedchem.3c02209. Epub 2024 Feb 19. J Med Chem. 2024. PMID: 38373290
Structural role of K224 in taniborbactam inhibition of NDM-1.
Ono D, Mojica MF, Bethel CR, Ishii Y, Drusin SI, Moreno DM, Vila AJ, Bonomo RA. Ono D, et al. Among authors: mojica mf. Antimicrob Agents Chemother. 2024 Feb 7;68(2):e0133223. doi: 10.1128/aac.01332-23. Epub 2024 Jan 4. Antimicrob Agents Chemother. 2024. PMID: 38174924 Free PMC article.
52 results