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Single cell and spatial analysis of immune-hot and immune-cold tumours identifies fibroblast subtypes associated with distinct immunological niches and positive immunotherapy response.
Jenkins BH, Tracy I, Rodrigues MFSD, Smith MJL, Martinez BR, Edmond M, Mahadevan S, Rao A, Zong H, Liu K, Aggarwal A, Li L, Diehl L, King EV, Bates JG, Hanley CJ, Thomas GJ. Jenkins BH, et al. Among authors: thomas gj. Mol Cancer. 2025 Jan 6;24(1):3. doi: 10.1186/s12943-024-02191-9. Mol Cancer. 2025. PMID: 39757146 Free PMC article.
Differentiation signals induce APOBEC3A expression via GRHL3 in squamous epithelia and squamous cell carcinoma.
Smith NJ, Reddin I, Policelli P, Oh S, Zainal N, Howes E, Jenkins B, Tracy I, Edmond M, Sharpe B, Amendra D, Zheng K, Egawa N, Doorbar J, Rao A, Mahadevan S, Carpenter MA, Harris RS, Ali S, Hanley C, Buisson R, King E, Thomas GJ, Fenton TR. Smith NJ, et al. Among authors: thomas gj. EMBO J. 2025 Jan;44(1):1-29. doi: 10.1038/s44318-024-00298-9. Epub 2024 Nov 15. EMBO J. 2025. PMID: 39548236 Free PMC article.
Author Correction: mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype.
Herranz N, Gallage S, Mellone M, Wuestefeld T, Klotz S, Hanley CJ, Raguz S, Acosta JC, Innes AJ, Banito A, Georgilis A, Montoya A, Wolter K, Dharmalingam G, Faull P, Carroll T, Martínez-Barbera JP, Cutillas P, Reisinger F, Heikenwalder M, Miller RA, Withers D, Zender L, Thomas GJ, Gil J. Herranz N, et al. Among authors: thomas gj. Nat Cell Biol. 2024 Jun;26(6):1019. doi: 10.1038/s41556-024-01443-6. Nat Cell Biol. 2024. PMID: 38778130 No abstract available.
Differentiation signals induce APOBEC3A expression via GRHL3 in squamous epithelia and squamous cell carcinoma.
Smith NJ, Reddin I, Policelli P, Oh S, Zainal N, Howes E, Jenkins B, Tracy I, Edmond M, Sharpe B, Amendra D, Zheng K, Egawa N, Doorbar J, Rao A, Mahadevan S, Carpenter MA, Harris RS, Ali S, Hanley C, Buisson R, King E, Thomas GJ, Fenton TR. Smith NJ, et al. Among authors: thomas gj. Res Sq [Preprint]. 2024 Mar 4:rs.3.rs-3997426. doi: 10.21203/rs.3.rs-3997426/v1. Res Sq. 2024. Update in: EMBO J. 2025 Jan;44(1):1-29. doi: 10.1038/s44318-024-00298-9 PMID: 38496447 Free PMC article. Updated. Preprint.
COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells.
McHugh D, Sun B, Gutierrez-Muñoz C, Hernández-González F, Mellone M, Guiho R, Duran I, Pombo J, Pietrocola F, Birch J, Kallemeijn WW, Khadayate S, Dharmalingam G, Vernia S, Tate EW, Martínez-Barbera JP, Withers DJ, Thomas GJ, Serrano M, Gil J. McHugh D, et al. Among authors: thomas gj. Nat Cell Biol. 2023 Dec;25(12):1804-1820. doi: 10.1038/s41556-023-01287-6. Epub 2023 Nov 27. Nat Cell Biol. 2023. PMID: 38012402 Free PMC article.
A high-throughput 3D X-ray histology facility for biomedical research and preclinical applications.
Katsamenis OL, Basford PJ, Robinson SK, Boardman RP, Konstantinopoulou E, Lackie PM, Page A, Ratnayaka JA, Goggin PM, Thomas GJ, Cox SJ, Sinclair I, Schneider P. Katsamenis OL, et al. Among authors: thomas gj. Wellcome Open Res. 2023 Dec 8;8:366. doi: 10.12688/wellcomeopenres.19666.1. eCollection 2023. Wellcome Open Res. 2023. PMID: 37928208 Free PMC article.
484 results