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A pathogenic mutation in the ALS/FTD gene VCP induces mitochondrial hypermetabolism by modulating the permeability transition pore.
Vanderhaeghe S, Prerad J, Tharkeshwar AK, Goethals E, Vints K, Beckers J, Scheveneels W, Debroux E, Princen K, Van Damme P, Fivaz M, Griffioen G, Van Den Bosch L. Vanderhaeghe S, et al. Among authors: princen k. Acta Neuropathol Commun. 2024 Oct 10;12(1):161. doi: 10.1186/s40478-024-01866-0. Acta Neuropathol Commun. 2024. PMID: 39390590 Free PMC article.
Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer's disease.
Princen K, Van Dooren T, van Gorsel M, Louros N, Yang X, Dumbacher M, Bastiaens I, Coupet K, Dupont S, Cuveliers E, Lauwers A, Laghmouchi M, Vanwelden T, Carmans S, Van Damme N, Duhamel H, Vansteenkiste S, Prerad J, Pipeleers K, Rodiers O, De Ridder L, Claes S, Busschots Y, Pringels L, Verhelst V, Debroux E, Brouwer M, Lievens S, Tavernier J, Farinelli M, Hughes-Asceri S, Voets M, Winderickx J, Wera S, de Wit J, Schymkowitz J, Rousseau F, Zetterberg H, Cummings JL, Annaert W, Cornelissen T, De Winter H, De Witte K, Fivaz M, Griffioen G. Princen K, et al. Science. 2024 May 31;384(6699):eadd6260. doi: 10.1126/science.add6260. Epub 2024 May 31. Science. 2024. PMID: 38815015
iPSC-derived cortical neurons to study sporadic Alzheimer disease: A transcriptome comparison with post-mortem brain samples.
Verheijen MCT, Krauskopf J, Caiment F, Nazaruk M, Wen QF, van Herwijnen MHM, Hauser DA, Gajjar M, Verfaillie C, Vermeiren Y, De Deyn PP, Wittens MMJ, Sieben A, Engelborghs S, Dejonckheere W, Princen K, Griffioen G, Roggen EL, Briedé JJ. Verheijen MCT, et al. Among authors: princen k. Toxicol Lett. 2022 Mar 1;356:89-99. doi: 10.1016/j.toxlet.2021.12.009. Epub 2021 Dec 15. Toxicol Lett. 2022. PMID: 34921933 Free article.
Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer's disease.
Dumbacher M, Van Dooren T, Princen K, De Witte K, Farinelli M, Lievens S, Tavernier J, Dehaen W, Wera S, Winderickx J, Allasia S, Kilonda A, Spieser S, Marchand A, Chaltin P, Hoogenraad CC, Griffioen G. Dumbacher M, et al. Among authors: princen k. Mol Neurodegener. 2018 Sep 26;13(1):50. doi: 10.1186/s13024-018-0283-3. Mol Neurodegener. 2018. PMID: 30257685 Free PMC article.
Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication.
Skerlj RT, Bridger GJ, Kaller A, McEachern EJ, Crawford JB, Zhou Y, Atsma B, Langille J, Nan S, Veale D, Wilson T, Harwig C, Hatse S, Princen K, De Clercq E, Schols D. Skerlj RT, et al. Among authors: princen k. J Med Chem. 2010 Apr 22;53(8):3376-88. doi: 10.1021/jm100073m. J Med Chem. 2010. PMID: 20297846
28 results