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Aplospojaveedins A-C, unusual sulfur-containing alkaloids produced by the endophytic fungus Aplosporella javeedii using OSMAC strategy.
Gao Y, Frank M, Teusch N, Woschko D, Janiak C, Mándi A, Kurtán T, Hartmann R, Schiedlauske K, van Geelen L, Kalscheuer R, Kaiser J, Gertzen CGW, Gohlke H, Wang BG, Proksch P, Liu Z. Gao Y, et al. Among authors: van geelen l. Front Microbiol. 2024 Sep 27;15:1458622. doi: 10.3389/fmicb.2024.1458622. eCollection 2024. Front Microbiol. 2024. PMID: 39397793 Free PMC article.
Novel 4-nitroimidazole analogues: synthesis, in vitro biological evaluation, in silico studies, and molecular dynamics simulation.
Al-Soud YA, Al-Sawakhnah SO, Al-Qawasmeh RA, Al-Masoudi NA, Al-Ahmad AH, Al-Maliki L, van Geelen L, Kalscheuer R, Saeed BA, Shtaiwi A, Stark H. Al-Soud YA, et al. Among authors: van geelen l. Z Naturforsch C J Biosci. 2024 Apr 8;79(3-4):61-71. doi: 10.1515/znc-2023-0146. Print 2024 Mar 25. Z Naturforsch C J Biosci. 2024. PMID: 38578162
Colletodiol derivatives of the endophytic fungus Trichocladium sp.
Simons VE, Mándi A, Frank M, van Geelen L, Tran-Cong N, Albrecht D, Coort A, Gebhard C, Kurtán T, Kalscheuer R. Simons VE, et al. Among authors: van geelen l. Fitoterapia. 2024 Jun;175:105914. doi: 10.1016/j.fitote.2024.105914. Epub 2024 Mar 19. Fitoterapia. 2024. PMID: 38508500 Free article.
Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria.
Junk L, Schmiedel VM, Guha S, Fischel K, Greb P, Vill K, Krisilia V, van Geelen L, Rumpel K, Kaur P, Krishnamurthy RV, Narayanan S, Shandil RK, Singh M, Kofink C, Mantoulidis A, Biber P, Gmaschitz G, Kazmaier U, Meinhart A, Leodolter J, Hoi D, Junker S, Morreale FE, Clausen T, Kalscheuer R, Weinstabl H, Boehmelt G. Junk L, et al. Among authors: van geelen l. Nat Commun. 2024 Mar 5;15(1):2005. doi: 10.1038/s41467-024-46218-7. Nat Commun. 2024. PMID: 38443338 Free PMC article.
Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival.
Hoi DM, Junker S, Junk L, Schwechel K, Fischel K, Podlesainski D, Hawkins PME, van Geelen L, Kaschani F, Leodolter J, Morreale FE, Kleine S, Guha S, Rumpel K, Schmiedel VM, Weinstabl H, Meinhart A, Payne RJ, Kaiser M, Hartl M, Boehmelt G, Kazmaier U, Kalscheuer R, Clausen T. Hoi DM, et al. Among authors: van geelen l. Cell. 2023 May 11;186(10):2176-2192.e22. doi: 10.1016/j.cell.2023.04.009. Epub 2023 May 2. Cell. 2023. PMID: 37137307 Free article.
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