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Genetic Risk of Reticular Pseudodrusen in Age-Related Macular Degeneration: HTRA1 /lncRNA BX842242.1 dominates, with no evidence for Complement Cascade involvement.
Farashi S, Abbott CJ, Ansell BR, Wu Z, Altay L, Arnon E, Arnould L, Bagdasarova Y, Balaskas K, Chen FK, Chew E, Chowers I, Clarke S, Cukras C, Delcourt C, Delyfer MN, den Hollander AI, Fauser S, Finger RP, Gabrielle PH, Han J, Hodgson LA, Hogg R, Holz FG, Hoyng C, Kumar H, Lad EM, Lee A, Luhmann UF, Mauschitz MM, McKnight AJ, McLenachan S, Mishra A, Moghul I, Orozco LD, Sampson DM, Scott LW, Sitnilska V, Song S, Stockwell A, Swaroop A, Terheyden JH, Tiosano L, Tufail A, Yaspan BL; MACUSTAR consortium; NICOLA consortium; Pébay A, Fletcher EL, Guymer RH, Bahlo M. Farashi S, et al. Among authors: guymer rh. medRxiv [Preprint]. 2024 Sep 28:2024.09.26.24314339. doi: 10.1101/2024.09.26.24314339. medRxiv. 2024. PMID: 39399049 Free PMC article. Preprint.
Deep Learning-Based Detection of Reticular Pseudodrusen in Age-Related Macular Degeneration on Optical Coherence Tomography.
Kumar H, Bagdasarova Y, Song S, Hickey DG, Cohn AC, Okada M, Finger RP, Terheyden JH, Hogg RE, Gabrielle PH, Arnould L, Jannaud M, Hadoux X, van Wijngaarden P, Abbott CJ, Hodgson LAB, Schwartz R, Tufail A, Chew EY, Lee CS, Fletcher EL, Bahlo M, Ansell BRE, Pébay A, Guymer RH, Lee AY, Wu Z. Kumar H, et al. Among authors: guymer rh. medRxiv [Preprint]. 2024 Sep 12:2024.09.11.24312817. doi: 10.1101/2024.09.11.24312817. medRxiv. 2024. PMID: 39314940 Free PMC article. Preprint.
Replenishing Age-Related Decline of IRAK-M Expression in Retinal Pigment Epithelium Attenuates Outer Retinal Degeneration.
Liu J, Copland DA, Clare AJ, Gorski M, Richards BT, Scott L, Theodoropoulou S, Greferath U, Cox K, Bell OH, Ou K, Powell JLB, Wu J, Robles LM, Li Y, Nicholson LB, Coffey PJ, Fletcher EL, Guymer R, Radeke MJ, Heid IM, Hageman GS, Chan YK, Dick AD. Liu J, et al. bioRxiv [Preprint]. 2023 Sep 29:2023.09.27.559733. doi: 10.1101/2023.09.27.559733. bioRxiv. 2023. Update in: Sci Transl Med. 2024 Jun 5;16(750):eadi4125. doi: 10.1126/scitranslmed.adi4125 PMID: 37808640 Free PMC article. Updated. Preprint.
Pegcetacoplan for the treatment of geographic atrophy due to age-related macular degeneration: a plain language summary of OAKS and DERBY clinical studies.
Heier JS, Lad EM, Holz FG, Rosenfeld PJ, Guymer RH, Boyer D, Grossi F, Baumal CR, Korobelnik JF, Slakter JS, Waheed NK, Metlapally R, Pearce I, Steinle N, Francone AA, Hu A, Lally DR, Deschatelets P, Francois C, Bliss C, Staurenghi G, Monés J, Singh RP, Ribeiro R, Wykoff CC. Heier JS, et al. Among authors: guymer rh. Immunotherapy. 2025 Jan 17:1-15. doi: 10.1080/1750743X.2025.2449760. Online ahead of print. Immunotherapy. 2025. PMID: 39819346 Free article.
Risk assessment models: considerations prior to use in clinical practice.
Darzi AJ, Busse JW, Torabiardakani K, Phillips M, Thabane L, Bhandari M, Borrelli E, Steel DH, Wykoff CC, Chaudhary V; Retina Evidence and Trials INternational Alliance (R.E.T.I.N.A.) Study Group. Darzi AJ, et al. Eye (Lond). 2024 Dec 18. doi: 10.1038/s41433-024-03557-5. Online ahead of print. Eye (Lond). 2024. PMID: 39695254 No abstract available.
Genome-wide association analyses identify distinct genetic architectures for age-related macular degeneration across ancestries.
Gorman BR, Voloudakis G, Igo RP Jr, Kinzy T, Halladay CW, Bigdeli TB, Zeng B, Venkatesh S, Cooke Bailey JN, Crawford DC, Markianos K, Dong F, Schreiner PA, Zhang W; VA Million Veteran Program; International AMD Genomics Consortium (IAMDGC); Hadi T, Anger MD, Stockwell A, Melles RB, Yin J, Choquet H, Kaye R, Patasova K, Patel PJ, Yaspan BL, Jorgenson E, Hysi PG, Lotery AJ, Gaziano JM, Tsao PS, Fliesler SJ, Sullivan JM, Greenberg PB, Wu WC, Assimes TL, Pyarajan S, Roussos P, Peachey NS, Iyengar SK. Gorman BR, et al. Nat Genet. 2024 Dec;56(12):2659-2671. doi: 10.1038/s41588-024-01764-0. Epub 2024 Dec 2. Nat Genet. 2024. PMID: 39623103
364 results