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32 results

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Page 1
Safety, tolerability, and efficacy of fasudil in amyotrophic lateral sclerosis (ROCK-ALS): a phase 2, randomised, double-blind, placebo-controlled trial.
Koch JC, Leha A, Bidner H, Cordts I, Dorst J, Günther R, Zeller D, Braun N, Metelmann M, Corcia P, De La Cruz E, Weydt P, Meyer T, Großkreutz J, Soriani MH, Attarian S, Weishaupt JH, Weyen U, Kuttler J, Zurek G, Rogers ML, Feneberg E, Deschauer M, Neuwirth C, Wuu J, Ludolph AC, Schmidt J, Remane Y, Camu W, Friede T, Benatar M, Weber M, Lingor P; ROCK-ALS Study group. Koch JC, et al. Among authors: weyen u. Lancet Neurol. 2024 Nov;23(11):1133-1146. doi: 10.1016/S1474-4422(24)00373-9. Lancet Neurol. 2024. PMID: 39424560 Free article. Clinical Trial.
SOD1 gene screening in ALS - frequency of mutations, patients' attitudes to genetic information and transition to tofersen treatment in a multi-center program.
Meyer T, Schumann P, Grehl T, Weyen U, Petri S, Rödiger A, Steinbach R, Grosskreutz J, Bernsen S, Weydt P, Wolf J, Günther R, Vidovic M, Baum P, Metelmann M, Weishaupt JH, Streubel B, Kasper DC, Koc Y, Kettemann D, Norden J, Schmitt P, Walter B, Münch C, Spittel S, Maier A, Körtvélyessy P. Meyer T, et al. Among authors: weyen u. Amyotroph Lateral Scler Frontotemporal Degener. 2024 Sep 13:1-10. doi: 10.1080/21678421.2024.2401131. Online ahead of print. Amyotroph Lateral Scler Frontotemporal Degener. 2024. PMID: 39268612
User expectations and experiences of an assistive robotic arm in amyotrophic lateral sclerosis: a multicenter observational study.
Spittel S, Meyer T, Weyen U, Grehl T, Weydt P, Steinbach R, Petri S, Baum P, Metelmann M, Sperfeld AD, Kettemann D, Norden J, Rödiger A, Ilse B, Grosskreutz J, Hildebrandt B, Walter B, Münch C, Maier A. Spittel S, et al. Among authors: weyen u. Neurol Res Pract. 2024 Aug 23;6(1):42. doi: 10.1186/s42466-024-00342-3. Neurol Res Pract. 2024. PMID: 39180054 Free PMC article.
Tofersen decreases neurofilament levels supporting the pathogenesis of the SOD1 p.D91A variant in amyotrophic lateral sclerosis patients.
Weishaupt JH, Körtvélyessy P, Schumann P, Valkadinov I, Weyen U, Hesebeck-Brinckmann J, Weishaupt K, Endres M, Andersen PM, Regensburger M, Dreger M, Koch JC, Conrad J, Meyer T. Weishaupt JH, et al. Among authors: weyen u. Commun Med (Lond). 2024 Jul 25;4(1):150. doi: 10.1038/s43856-024-00573-0. Commun Med (Lond). 2024. PMID: 39054363 Free PMC article.
Clinical and patient-reported outcomes and neurofilament response during tofersen treatment in SOD1-related ALS-A multicenter observational study over 18 months.
Meyer T, Schumann P, Weydt P, Petri S, Weishaupt JH, Weyen U, Koch JC, Günther R, Regensburger M, Boentert M, Wiesenfarth M, Koc Y, Kolzarek F, Kettemann D, Norden J, Bernsen S, Elmas Z, Conrad J, Valkadinov I, Vidovic M, Dorst J, Ludolph AC, Hesebeck-Brinckmann J, Spittel S, Münch C, Maier A, Körtvélyessy P. Meyer T, et al. Among authors: weyen u. Muscle Nerve. 2024 Sep;70(3):333-345. doi: 10.1002/mus.28182. Epub 2024 Jun 20. Muscle Nerve. 2024. PMID: 39031772
Patients' and caregivers' perception of multidimensional and palliative care in amyotrophic lateral sclerosis - protocol of a German multicentre study.
Linse K, Weber C, Reilich P, Schöberl F, Boentert M, Petri S, Rödiger A, Posa A, Otto M, Wolf J, Zeller D, Brunkhorst R, Koch J, Hermann A, Großkreutz J, Schröter C, Groß M, Lingor P, Machetanz G, Semmler L, Dorst J, Lulé D, Ludolph A, Meyer T, Maier A, Metelmann M, Regensburger M, Winkler J, Schrank B, Kohl Z, Hagenacker T, Brakemeier S, Weyen U, Weiler M, Lorenzl S, Bublitz S, Weydt P, Grehl T, Kotterba S, Lapp HS, Freigang M, Vidovic M, Aust E, Günther R. Linse K, et al. Among authors: weyen u. Neurol Res Pract. 2024 Jul 4;6(1):34. doi: 10.1186/s42466-024-00328-1. Neurol Res Pract. 2024. PMID: 38961496 Free PMC article.
Serum neurofilament light chain in distinct phenotypes of amyotrophic lateral sclerosis: A longitudinal, multicenter study.
Meyer T, Dreger M, Grehl T, Weyen U, Kettemann D, Weydt P, Günther R, Lingor P, Petri S, Koch JC, Großkreutz J, Rödiger A, Baum P, Hermann A, Prudlo J, Boentert M, Weishaupt JH, Löscher WN, Dorst J, Koc Y, Bernsen S, Cordts I, Vidovic M, Steinbach R, Metelmann M, Kleinveld VE, Norden J, Ludolph A, Walter B, Schumann P, Münch C, Körtvélyessy P, Maier A. Meyer T, et al. Among authors: weyen u. Eur J Neurol. 2024 Sep;31(9):e16379. doi: 10.1111/ene.16379. Epub 2024 Jun 10. Eur J Neurol. 2024. PMID: 38859579 Free PMC article.
Effects of tofersen treatment in patients with SOD1-ALS in a "real-world" setting - a 12-month multicenter cohort study from the German early access program.
Wiesenfarth M, Dorst J, Brenner D, Elmas Z, Parlak Ö, Uzelac Z, Kandler K, Mayer K, Weiland U, Herrmann C, Schuster J, Freischmidt A, Müller K, Siebert R, Bachhuber F, Simak T, Günther K, Fröhlich E, Knehr A, Regensburger M, German A, Petri S, Grosskreutz J, Klopstock T, Reilich P, Schöberl F, Hagenacker T, Weyen U, Günther R, Vidovic M, Jentsch M, Haarmeier T, Weydt P, Valkadinov I, Hesebeck-Brinckmann J, Conrad J, Weishaupt JH, Schumann P, Körtvélyessy P, Meyer T, Ruf WP, Witzel S, Senel M, Tumani H, Ludolph AC. Wiesenfarth M, et al. Among authors: weyen u. EClinicalMedicine. 2024 Feb 15;69:102495. doi: 10.1016/j.eclinm.2024.102495. eCollection 2024 Mar. EClinicalMedicine. 2024. PMID: 38384337 Free PMC article.
32 results