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A distinct metabolic and epigenetic state drives trained immunity in HSC-derived macrophages from autoimmune mice.
Mills TS, Kain B, Burchill MA, Danis E, Lucas ED, Culp-Hill R, Cowan CM, Schleicher WE, Patel SB, Tran BT, Cao R, Goodspeed A, Ferrara S, Bevers S, Jirón Tamburini BA, Roede JR, D'Alessandro A, King KY, Pietras EM. Mills TS, et al. Cell Stem Cell. 2024 Nov 7;31(11):1630-1649.e8. doi: 10.1016/j.stem.2024.09.010. Epub 2024 Oct 15. Cell Stem Cell. 2024. PMID: 39413777
An iron rheostat controls hematopoietic stem cell fate.
Kao YR, Chen J, Kumari R, Ng A, Zintiridou A, Tatiparthy M, Ma Y, Aivalioti MM, Moulik D, Sundaravel S, Sun D, Reisz JA, Grimm J, Martinez-Lopez N, Stransky S, Sidoli S, Steidl U, Singh R, D'Alessandro A, Will B. Kao YR, et al. Cell Stem Cell. 2024 Mar 7;31(3):378-397.e12. doi: 10.1016/j.stem.2024.01.011. Epub 2024 Feb 22. Cell Stem Cell. 2024. PMID: 38402617 Free article.
Lysosomal acid lipase A modulates leukemia stem cell response to venetoclax/tyrosine kinase inhibitor combination therapy in blast phase chronic myeloid leukemia.
Minhajuddin M, Winters A, Ye H, Pei S, Stevens B, Gillen A, Engel K, Gipson S, Ransom M, Amaya M, Inguva A, Gasparetto M, Althoff MJ, Miller R, Shelton I, Tolison H, Krug A, Culp-Hill R, D'Alessandro A, Sherbenou DW, Pollyea DA, Smith C, Jordan CT. Minhajuddin M, et al. Haematologica. 2025 Jan 1;110(1):103-116. doi: 10.3324/haematol.2023.284716. Haematologica. 2025. PMID: 38934082 Free PMC article.
Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis.
Ionescu RB, Nicaise AM, Reisz JA, Williams EC, Prasad P, Willis CM, Simões-Abade MBC, Sbarro L, Dzieciatkowska M, Stephenson D, Suarez Cubero M, Rizzi S, Pirvan L, Peruzzotti-Jametti L, Fossati V, Edenhofer F, Leonardi T, Frezza C, Mohorianu I, D'Alessandro A, Pluchino S. Ionescu RB, et al. Cell Stem Cell. 2024 Nov 7;31(11):1574-1590.e11. doi: 10.1016/j.stem.2024.09.014. Epub 2024 Oct 21. Cell Stem Cell. 2024. PMID: 39437792 Free article.
Myelomonocytic cells in giant cell arteritis activate trained immunity programs sustaining inflammation and cytokine production.
Cantoni E, Merelli I, Stefanoni D, Tomelleri A, Campochiaro C, Giordano V, Panigada M, Baldissera EM, Merlo Pich L, Natoli V, Ziogas A, Domínguez-Andrés J, De Luca G, Mazza D, Zambrano S, Gnani D, Ferrarini M, Ferrero E, Agresti A, Vergani B, Leone BE, Cenci S, Ravelli A, Matucci-Cerinic M, D'Alessandro A, Joosten LAB, Dagna L, Netea MG, Molteni R, Cavalli G. Cantoni E, et al. Rheumatology (Oxford). 2023 Oct 3;62(10):3469-3479. doi: 10.1093/rheumatology/kead061. Rheumatology (Oxford). 2023. PMID: 36802235
Lactoylglutathione promotes inflammatory signaling in macrophages through histone lactoylation.
Trujillo MN, Jennings EQ, Hoffman EA, Zhang H, Phoebe AM, Mastin GE, Kitamura N, Reisz JA, Megill E, Kantner D, Marcinkiewicz MM, Twardy SM, Lebario F, Chapman E, McCullough RL, D'Alessandro A, Snyder NW, Cusanovich DA, Galligan JJ. Trujillo MN, et al. Mol Metab. 2024 Mar;81:101888. doi: 10.1016/j.molmet.2024.101888. Epub 2024 Feb 1. Mol Metab. 2024. PMID: 38307385 Free PMC article.
Role of the afferent lymph as an immunological conduit to analyze tissue antigenic and inflammatory load.
Nanaware PP, Khan ZN, Clement CC, Shetty M, Mota I, Seltzer ES, Dzieciatkowska M, Gamboni F, D'Alessandro A, Ng C, Nagayama M, Lichti CF, Soni RK, Jacob B Geri, Matei I, Lyden D, Longman R, Lu TT, Wan X, Unanue ER, Stern LJ, Santambrogio L. Nanaware PP, et al. Cell Rep. 2024 Jun 25;43(6):114311. doi: 10.1016/j.celrep.2024.114311. Epub 2024 Jun 5. Cell Rep. 2024. PMID: 38848214 Free PMC article.
Simultaneous targeting of PD-1 and IL-2Rβγ with radiation therapy inhibits pancreatic cancer growth and metastasis.
Piper M, Hoen M, Darragh LB, Knitz MW, Nguyen D, Gadwa J, Durini G, Karakoc I, Grier A, Neupert B, Van Court B, Abdelazeem KNM, Yu J, Olimpo NA, Corbo S, Ross RB, Pham TT, Joshi M, Kedl RM, Saviola AJ, Amann M, Umaña P, Codarri Deak L, Klein C, D'Alessandro A, Karam SD. Piper M, et al. Cancer Cell. 2023 May 8;41(5):950-969.e6. doi: 10.1016/j.ccell.2023.04.001. Epub 2023 Apr 27. Cancer Cell. 2023. PMID: 37116489 Free PMC article.
1,341 results