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Knockdown of Ketohexokinase Versus Inhibition of Its Kinase Activity Exert Divergent Effects on Fructose Metabolism.
Park SH, Fadhul T, Conroy LR, Clarke HA, Sun RC, Wallenius K, Boucher J, O'Mahony G, Boianelli A, Persson M, Jung S, Jang C, Loria AS, Martinez GJ, Kipp ZA, Bates EA, Hinds TD Jr, Divanovic S, Softic S. Park SH, et al. JCI Insight. 2024 Oct 17:e184396. doi: 10.1172/jci.insight.184396. Online ahead of print. JCI Insight. 2024. PMID: 39418102 Free article.
Ketohexokinase-C regulates global protein acetylation to decrease carnitine palmitoyltransferase 1a-mediated fatty acid oxidation.
Helsley RN, Park SH, Vekaria HJ, Sullivan PG, Conroy LR, Sun RC, Romero MDM, Herrero L, Bons J, King CD, Rose J, Meyer JG, Schilling B, Kahn CR, Softic S. Helsley RN, et al. Among authors: park sh. J Hepatol. 2023 Jul;79(1):25-42. doi: 10.1016/j.jhep.2023.02.010. Epub 2023 Feb 21. J Hepatol. 2023. PMID: 36822479 Free PMC article.
Loss of carnitine palmitoyltransferase 1a reduces docosahexaenoic acid-containing phospholipids and drives sexually dimorphic liver disease in mice.
Zelows MM, Cady C, Dharanipragada N, Mead AE, Kipp ZA, Bates EA, Varadharajan V, Banerjee R, Park SH, Shelman NR, Clarke HA, Hawkinson TR, Medina T, Sun RC, Lydic TA, Hinds TD Jr, Brown JM, Softic S, Graf GA, Helsley RN. Zelows MM, et al. Among authors: park sh. Mol Metab. 2023 Dec;78:101815. doi: 10.1016/j.molmet.2023.101815. Epub 2023 Oct 4. Mol Metab. 2023. PMID: 37797918 Free PMC article.
Fructose Induced KHK-C Increases ER Stress and Modulates Hepatic Transcriptome to Drive Liver Disease in Diet-Induced and Genetic Models of NAFLD.
Park SH, Helsley RN, Fadhul T, Willoughby JLS, Noetzli L, Tu HC, Solheim MH, Fujisaka S, Pan H, Dreyfuss JM, Bons J, Rose J, King CD, Schilling B, Lusis AJ, Pan C, Gupta M, Kulkarni RN, Fitzgerald K, Kern PA, Divanovic S, Kahn CR, Softic S. Park SH, et al. bioRxiv [Preprint]. 2023 Jan 27:2023.01.27.525605. doi: 10.1101/2023.01.27.525605. bioRxiv. 2023. Update in: Metabolism. 2023 Aug;145:155591. doi: 10.1016/j.metabol.2023.155591. PMID: 36747758 Free PMC article. Updated. Preprint.
Fructose induced KHK-C can increase ER stress independent of its effect on lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD.
Park SH, Helsley RN, Fadhul T, Willoughby JLS, Noetzli L, Tu HC, Solheim MH, Fujisaka S, Pan H, Dreyfuss JM, Bons J, Rose J, King CD, Schilling B, Lusis AJ, Pan C, Gupta M, Kulkarni RN, Fitzgerald K, Kern PA, Divanovic S, Kahn CR, Softic S. Park SH, et al. Metabolism. 2023 Aug;145:155591. doi: 10.1016/j.metabol.2023.155591. Epub 2023 May 23. Metabolism. 2023. PMID: 37230214 Free PMC article.
Loss of Carnitine Palmitoyltransferase 1a Reduces Docosahexaenoic Acid-Containing Phospholipids and Drives Sexually Dimorphic Liver Disease in Mice.
Zelows MM, Cady C, Dharanipragada N, Mead AE, Kipp ZA, Bates EA, Varadharajan V, Banerjee R, Park SH, Shelman NR, Clarke HA, Hawkinson TR, Medina T, Sun RC, Lydic TA, Hinds TD, Brown JM, Softic S, Graf GA, Helsley RN. Zelows MM, et al. Among authors: park sh. bioRxiv [Preprint]. 2023 Aug 18:2023.08.17.553705. doi: 10.1101/2023.08.17.553705. bioRxiv. 2023. Update in: Mol Metab. 2023 Dec;78:101815. doi: 10.1016/j.molmet.2023.101815. PMID: 37645721 Free PMC article. Updated. Preprint.
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