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PAR2 on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451.
Bhansali D, Tu NH, Inoue K, Teng S, Li T, Tran HD, Kim DH, Dong J, Peach CJ, Sokrat B, Jensen DD, Dolan JC, Yamano S, Robinson VM, Bunnett NW, Albertson DG, Leong KW, Schmidt BL. Bhansali D, et al. Among authors: peach cj. Biomaterials. 2024 Oct 2;314:122874. doi: 10.1016/j.biomaterials.2024.122874. Online ahead of print. Biomaterials. 2024. PMID: 39418848
Mice expressing fluorescent PAR2 reveal that endocytosis mediates colonic inflammation and pain.
Latorre R, Hegron A, Peach CJ, Teng S, Tonello R, Retamal JS, Klein-Cloud R, Bok D, Jensen DD, Gottesman-Katz L, Rientjes J, Veldhuis NA, Poole DP, Schmidt BL, Pothoulakis CH, Rankin C, Xie Y, Koon HW, Bunnett NW. Latorre R, et al. Among authors: peach cj. Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e2112059119. doi: 10.1073/pnas.2112059119. Proc Natl Acad Sci U S A. 2022. PMID: 35110404 Free PMC article.
Protease-activated receptors in health and disease.
Peach CJ, Edgington-Mitchell LE, Bunnett NW, Schmidt BL. Peach CJ, et al. Physiol Rev. 2023 Jan 1;103(1):717-785. doi: 10.1152/physrev.00044.2021. Epub 2022 Jul 28. Physiol Rev. 2023. PMID: 35901239 Free PMC article. Review.
Therapeutic antagonism of the neurokinin 1 receptor in endosomes provides sustained pain relief.
Hegron A, Peach CJ, Tonello R, Seemann P, Teng S, Latorre R, Huebner H, Weikert D, Rientjes J, Veldhuis NA, Poole DP, Jensen DD, Thomsen ARB, Schmidt BL, Imlach WL, Gmeiner P, Bunnett NW. Hegron A, et al. Among authors: peach cj. Proc Natl Acad Sci U S A. 2023 May 30;120(22):e2220979120. doi: 10.1073/pnas.2220979120. Epub 2023 May 22. Proc Natl Acad Sci U S A. 2023. PMID: 37216510 Free PMC article.
Neuropilin-1 is a co-receptor for Nerve Growth Factor-evoked pain.
Peach CJ, Tonello R, Damo E, Gomez K, Calderon-Rivera A, Bruni R, Bansia H, Maile L, Manu AM, Hahn H, Thomsen ARB, Schmidt BL, Davidson S, des Georges A, Khanna R, Bunnett NW. Peach CJ, et al. bioRxiv [Preprint]. 2024 Oct 21:2023.12.06.570398. doi: 10.1101/2023.12.06.570398. bioRxiv. 2024. PMID: 38106002 Free PMC article. Preprint.
Complex Formation between VEGFR2 and the β2-Adrenoceptor.
Kilpatrick LE, Alcobia DC, White CW, Peach CJ, Glenn JR, Zimmerman K, Kondrashov A, Pfleger KDG, Ohana RF, Robers MB, Wood KV, Sloan EK, Woolard J, Hill SJ. Kilpatrick LE, et al. Among authors: peach cj. Cell Chem Biol. 2019 Jun 20;26(6):830-841.e9. doi: 10.1016/j.chembiol.2019.02.014. Epub 2019 Apr 4. Cell Chem Biol. 2019. PMID: 30956148 Free PMC article.
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