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621 results

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Page 1
Efficacy, safety and tolerability of GSK3858279, an anti-CCL17 monoclonal antibody and analgesic, in healthy volunteers and patients with knee osteoarthritis pain: a phase I, randomised, double-blind, placebo-controlled, proof-of-mechanism and proof-of-concept study.
Nijjar JS, Abbott-Banner K, Alvarez Y, Aston N, Bass D, Bentley JH, Ellis J, Ellson C, Emery EC, Feeney M, Fernando D, Inman D, Kaur R, Modis LK, Munoz Vicente S, Muya C, Nistala K, Panoilia E, Ray R, Siederer S, Smith JE, Weir L, Wisniacki N. Nijjar JS, et al. Among authors: fernando d. Ann Rheum Dis. 2024 Oct 17:ard-2023-225434. doi: 10.1136/ard-2023-225434. Online ahead of print. Ann Rheum Dis. 2024. PMID: 39419538 Free article.
Assessment of the safety, pharmacokinetics and pharmacodynamics of GSK3335065, an inhibitor of kynurenine monooxygenase, in a randomised placebo-controlled first-in-human study in healthy volunteers.
Fernando D, Dimelow R, Gorey C, Zhu X, Muya C, Parker C, Wright W, Soleman S, Walsh S, Crause M, Vlasakakis G, Guiney W, Robertson N, Bergeal M, Cui Y, Krug AW, Uings I. Fernando D, et al. Br J Clin Pharmacol. 2022 Feb;88(2):865-870. doi: 10.1111/bcp.15010. Epub 2021 Aug 22. Br J Clin Pharmacol. 2022. PMID: 34327739 Free article. Clinical Trial.
Anti-IL-7 receptor α monoclonal antibody (GSK2618960) in healthy subjects - a randomized, double-blind, placebo-controlled study.
Ellis J, van Maurik A, Fortunato L, Gisbert S, Chen K, Schwartz A, McHugh S, Want A, Santos Franco S, Oliveira JJ, Price J, Coles A, Brown K, Su D, Craigen JL, Yang J, Brett S, Davis B, Cheriyan J, Kousin-Ezewu O, Gray F, Thompson PW, Fernando D. Ellis J, et al. Among authors: fernando d. Br J Clin Pharmacol. 2019 Feb;85(2):304-315. doi: 10.1111/bcp.13748. Epub 2018 Dec 3. Br J Clin Pharmacol. 2019. PMID: 30161291 Free PMC article. Clinical Trial.
Quantifying disease activity in rheumatoid arthritis with the TSPO PET ligand 18F-GE-180 and comparison with 18F-FDG and DCE-MRI.
de Groot M, Patel N, Manavaki R, Janiczek RL, Bergstrom M, Östör A, Gerlag D, Roberts A, Graves MJ, Karkera Y, Fernando D, Mistry P, Walker A, Wisniacki N, Fryer TD, Jimenez-Royo P. de Groot M, et al. Among authors: fernando d. EJNMMI Res. 2019 Dec 19;9(1):113. doi: 10.1186/s13550-019-0576-8. EJNMMI Res. 2019. PMID: 31858293 Free PMC article.
CCL20 neutralization by a monoclonal antibody in healthy subjects selectively inhibits recruitment of CCR6+ cells in an experimental suction blister.
Bouma G, Zamuner S, Hicks K, Want A, Oliveira J, Choudhury A, Brett S, Robertson D, Felton L, Norris V, Fernando D, Herdman M, Tarzi R. Bouma G, et al. Among authors: fernando d. Br J Clin Pharmacol. 2017 Sep;83(9):1976-1990. doi: 10.1111/bcp.13286. Epub 2017 Apr 22. Br J Clin Pharmacol. 2017. PMID: 28295451 Free PMC article. Clinical Trial.
A randomized study of the safety and pharmacokinetics of GSK3358699, a mononuclear myeloid-targeted bromodomain and extra-terminal domain inhibitor.
Brown JA, Bal J, Simeoni M, Williams P, Mander PK, Soden PE, Daga S, Fahy WA, Wong GK, Bloomer JC, Erwig L, Cui Y, Fernando D, Carnaghan H, Banham-Hall EJ, Hopkins S, Davis BG, Oliveira JJD, Prinjha RK. Brown JA, et al. Among authors: fernando d. Br J Clin Pharmacol. 2022 May;88(5):2140-2155. doi: 10.1111/bcp.15137. Epub 2021 Dec 18. Br J Clin Pharmacol. 2022. PMID: 34773923 Free PMC article. Clinical Trial.
621 results