Polak S - Search Results

1

Mechanistic Model for Drug Release from PLGA-Based Biodegradable Implants for In Vitro Release Testing: Development and Validation.

Mittapelly N, Djehizian A, Telaprolu KC, McNally K, Puttrevu SK, Arjmandi-Tash O, Polak S, Bois FY. Mittapelly N, et al. Among authors: polak s. ACS Appl Bio Mater. 2024 Nov 18;7(11):7453-7465. doi: 10.1021/acsabm.4c01054. Epub 2024 Oct 18. ACS Appl Bio Mater. 2024. PMID: 39424342

2

Physiologically Based Pharmacokinetic Modeling of Transdermal Selegiline and Its Metabolites for the Evaluation of Disposition Differences between Healthy and Special Populations.

Puttrevu SK, Arora S, Polak S, Patel NK. Puttrevu SK, et al. Among authors: polak s. Pharmaceutics. 2020 Sep 30;12(10):942. doi: 10.3390/pharmaceutics12100942. Pharmaceutics. 2020. PMID: 33008144 Free PMC article.

3

Multi-phase multi-layer mechanistic dermal absorption (MPML MechDermA) model to predict local and systemic exposure of drug products applied on skin.

Patel N, Clarke JF, Salem F, Abdulla T, Martins F, Arora S, Tsakalozou E, Hodgkinson A, Arjmandi-Tash O, Cristea S, Ghosh P, Alam K, Raney SG, Jamei M, Polak S. Patel N, et al. Among authors: polak s. CPT Pharmacometrics Syst Pharmacol. 2022 Aug;11(8):1060-1084. doi: 10.1002/psp4.12814. Epub 2022 Jun 27. CPT Pharmacometrics Syst Pharmacol. 2022. PMID: 35670226 Free PMC article.

4

Modelling and simulation approaches to support formulation optimization, clinical development and regulatory assessment of the topically applied formulations - Nimesulide solution gel case study.

Mittapelly N, Polak S. Mittapelly N, et al. Among authors: polak s. Eur J Pharm Biopharm. 2022 Sep;178:140-149. doi: 10.1016/j.ejpb.2022.08.005. Epub 2022 Aug 17. Eur J Pharm Biopharm. 2022. PMID: 35985454

5

A novel physiologically based pharmacokinetic model of rectal absorption, evaluated and verified using clinical data on 10 rectally administered drugs.

Dancik Y, Mittapelly N, Puttrevu SK, Polak S. Dancik Y, et al. Among authors: polak s. Int J Pharm. 2023 Aug 25;643:123273. doi: 10.1016/j.ijpharm.2023.123273. Epub 2023 Jul 26. Int J Pharm. 2023. PMID: 37507097

6

Development and verification of mechanistic vaginal absorption and metabolism model to predict systemic exposure after vaginal ring and gel application.

Thakur K, Telaprolu KC, Paterson D, Salem F, Arora S, Polak S. Thakur K, et al. Among authors: polak s. Br J Clin Pharmacol. 2024 Jun;90(6):1428-1449. doi: 10.1111/bcp.16029. Epub 2024 Mar 7. Br J Clin Pharmacol. 2024. PMID: 38450818

7

Towards the understanding of the IVPT results variability-Development, verification and validation of the PBPK model of caffeine in vitro human skin permeation.

Krumpholz L, Polak S, Wiśniowska B. Krumpholz L, et al. Among authors: polak s. Eur J Pharm Sci. 2025 Jan 1;204:106943. doi: 10.1016/j.ejps.2024.106943. Epub 2024 Oct 20. Eur J Pharm Sci. 2025. PMID: 39437978 Free article.

8

Quantitative prediction of formulation-specific food effects and their population variability from in vitro data with the physiologically-based ADAM model: a case study using the BCS/BDDCS Class II drug nifedipine.

Patel N, Polak S, Jamei M, Rostami-Hodjegan A, Turner DB. Patel N, et al. Among authors: polak s. Eur J Pharm Sci. 2014 Jun 16;57:240-9. doi: 10.1016/j.ejps.2013.09.006. Epub 2013 Sep 21. Eur J Pharm Sci. 2014. PMID: 24060671

9

Mechanistic Physiologically Based Pharmacokinetic (PBPK) Model of the Heart Accounting for Inter-Individual Variability: Development and Performance Verification.

Tylutki Z, Mendyk A, Polak S. Tylutki Z, et al. Among authors: polak s. J Pharm Sci. 2018 Apr;107(4):1167-1177. doi: 10.1016/j.xphs.2017.11.012. Epub 2017 Nov 23. J Pharm Sci. 2018. PMID: 29175411

10

Better prediction of the local concentration-effect relationship: the role of physiologically based pharmacokinetics and quantitative systems pharmacology and toxicology in the evolution of model-informed drug discovery and development.

Polak S, Tylutki Z, Holbrook M, Wiśniowska B. Polak S, et al. Drug Discov Today. 2019 Jul;24(7):1344-1354. doi: 10.1016/j.drudis.2019.05.016. Epub 2019 May 24. Drug Discov Today. 2019. PMID: 31132414 Review.

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