Rynkiewicz MJ - Search Results

1

Distinct mechanisms drive divergent phenotypes in hypertrophic and dilated cardiomyopathy-associated TPM1 variants.

Halder SS, Rynkiewicz MJ, Kim L, Barry ME, Zied AG, Sewanan LR, Kirk JA, Moore JR, Lehman WJ, Campbell SG. Halder SS, et al. Among authors: rynkiewicz mj. J Clin Invest. 2024 Dec 16;134(24):e179135. doi: 10.1172/JCI179135. J Clin Invest. 2024. PMID: 39436707 Free PMC article.

2

Mechanisms of pathogenicity in the hypertrophic cardiomyopathy-associated TPM1 variant S215L.

Halder SS, Rynkiewicz MJ, Creso JG, Sewanan LR, Howland L, Moore JR, Lehman W, Campbell SG. Halder SS, et al. Among authors: rynkiewicz mj. PNAS Nexus. 2023 Jan 21;2(3):pgad011. doi: 10.1093/pnasnexus/pgad011. eCollection 2023 Mar. PNAS Nexus. 2023. PMID: 36896133 Free PMC article.

3

The Effect of Tropomyosin Mutations on Actin-Tropomyosin Binding: In Search of Lost Time.

Lehman W, Moore JR, Campbell SG, Rynkiewicz MJ. Lehman W, et al. Among authors: rynkiewicz mj. Biophys J. 2019 Jun 18;116(12):2275-2284. doi: 10.1016/j.bpj.2019.05.009. Epub 2019 May 13. Biophys J. 2019. PMID: 31130236 Free PMC article.

4

Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation.

Sewanan LR, Park J, Rynkiewicz MJ, Racca AW, Papoutsidakis N, Schwan J, Jacoby DL, Moore JR, Lehman W, Qyang Y, Campbell SG. Sewanan LR, et al. Among authors: rynkiewicz mj. J Gen Physiol. 2021 Sep 6;153(9):e202012640. doi: 10.1085/jgp.202012640. Epub 2021 Jul 28. J Gen Physiol. 2021. PMID: 34319370 Free PMC article.

5

Troponin-I-induced tropomyosin pivoting defines thin-filament function in relaxed and active muscle.

Lehman W, Rynkiewicz MJ. Lehman W, et al. Among authors: rynkiewicz mj. J Gen Physiol. 2023 Jul 3;155(7):e202313387. doi: 10.1085/jgp.202313387. Epub 2023 May 30. J Gen Physiol. 2023. PMID: 37249525 Free PMC article.

6

Glutamate 139 of tropomyosin is critical for cardiac thin filament blocked-state stabilization.

Barry ME, Rynkiewicz MJ, Pavadai E, Viana A, Lehman W, Moore JR. Barry ME, et al. Among authors: rynkiewicz mj. J Mol Cell Cardiol. 2024 Mar;188:30-37. doi: 10.1016/j.yjmcc.2024.01.004. Epub 2024 Jan 22. J Mol Cell Cardiol. 2024. PMID: 38266978

7

In silico and in vitro models reveal the molecular mechanisms of hypocontractility caused by TPM1 M8R.

Creso JG, Gokhan I, Rynkiewicz MJ, Lehman W, Moore JR, Campbell SG. Creso JG, et al. Among authors: rynkiewicz mj. Front Physiol. 2024 Aug 30;15:1452509. doi: 10.3389/fphys.2024.1452509. eCollection 2024. Front Physiol. 2024. PMID: 39282088 Free PMC article.

8

Precise Binding of Tropomyosin on Actin Involves Sequence-Dependent Variance in Coiled-Coil Twisting.

Lehman W, Li X, Kiani FA, Moore JR, Campbell SG, Fischer S, Rynkiewicz MJ. Lehman W, et al. Among authors: rynkiewicz mj. Biophys J. 2018 Sep 18;115(6):1082-1092. doi: 10.1016/j.bpj.2018.08.017. Epub 2018 Aug 18. Biophys J. 2018. PMID: 30195938 Free PMC article.

9

A new twist on tropomyosin binding to actin filaments: perspectives on thin filament function, assembly and biomechanics.

Lehman W, Rynkiewicz MJ, Moore JR. Lehman W, et al. Among authors: rynkiewicz mj. J Muscle Res Cell Motil. 2020 Mar;41(1):23-38. doi: 10.1007/s10974-019-09501-5. Epub 2019 Feb 15. J Muscle Res Cell Motil. 2020. PMID: 30771202 Free PMC article. Review.

10

Cardiomyopathy Mutation Alters End-to-End Junction of Tropomyosin and Reduces Calcium Sensitivity.

Sundar S, Rynkiewicz MJ, Ghosh A, Lehman W, Moore JR. Sundar S, et al. Among authors: rynkiewicz mj. Biophys J. 2020 Jan 21;118(2):303-312. doi: 10.1016/j.bpj.2019.11.3396. Epub 2019 Dec 14. Biophys J. 2020. PMID: 31882250 Free PMC article.

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