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Engineered AAV capsid transport mutants overcome transduction deficiencies in the aged CNS.
Sandoval IM, Kelley CM, Bernal-Conde LD, Steece-Collier K, Marmion DJ, Davidsson M, Crosson SM, Boye SL, Boye SE, Manfredsson FP. Sandoval IM, et al. Among authors: crosson sm. Mol Ther Nucleic Acids. 2024 Sep 12;35(4):102332. doi: 10.1016/j.omtn.2024.102332. eCollection 2024 Dec 10. Mol Ther Nucleic Acids. 2024. PMID: 39445231 Free PMC article.
Development of an AAV-CRISPR-Cas9-based treatment for dominant cone-rod dystrophy 6.
Mellen RW, Calabro KR, McCullough KT, Crosson SM, Cova A, Fajardo D, Xu E, Boye SL, Boye SE. Mellen RW, et al. Among authors: crosson sm. Mol Ther Methods Clin Dev. 2023 Jun 1;30:48-64. doi: 10.1016/j.omtm.2023.05.020. eCollection 2023 Sep 14. Mol Ther Methods Clin Dev. 2023. PMID: 37361352 Free PMC article.
Intravitreal injection of a rationally designed AAV capsid library in non-human primate identifies variants with enhanced retinal transduction and neutralizing antibody evasion.
Kellish PC, Marsic D, Crosson SM, Choudhury S, Scalabrino ML, Strang CE, Hill J, McCullough KT, Peterson JJ, Fajardo D, Gupte S, Makal V, Kondratov O, Kondratova L, Iyer S, Witherspoon CD, Gamlin PD, Zolotukhin S, Boye SL, Boye SE. Kellish PC, et al. Among authors: crosson sm. Mol Ther. 2023 Dec 6;31(12):3441-3456. doi: 10.1016/j.ymthe.2023.10.001. Epub 2023 Oct 9. Mol Ther. 2023. PMID: 37814449 Free article.
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