Cai X - Search Results

1

The de-sulfinylation enzyme sulfiredoxin-1 attenuates hepatic stellate cell activation and liver fibrosis by modulating the PTPN12-NLRP3 axis.

Kim JW, Tung HC, Ke M, Xu P, Cai X, Xi Y, Xu M, Ren S, Huang Y, Bhowmik A, Carroll KS, Bae YS, Li S, Xie W. Kim JW, et al. Among authors: cai x. Hepatology. 2024 Oct 24. doi: 10.1097/HEP.0000000000001133. Online ahead of print. Hepatology. 2024. PMID: 39446334

2

The anti-fibrotic drug pirfenidone inhibits liver fibrosis by targeting the small oxidoreductase glutaredoxin-1.

Xi Y, Li Y, Xu P, Li S, Liu Z, Tung HC, Cai X, Wang J, Huang H, Wang M, Xu M, Ren S, Li S, Zhang M, Lee YJ, Huang L, Yang D, He J, Huang Z, Xie W. Xi Y, et al. Among authors: cai x. Sci Adv. 2021 Sep 3;7(36):eabg9241. doi: 10.1126/sciadv.abg9241. Epub 2021 Sep 1. Sci Adv. 2021. PMID: 34516906 Free PMC article.

3

Inhibition of the SLC35B2-TPST2 Axis of Tyrosine Sulfation Attenuates the Growth and Metastasis of Pancreatic Ductal Adenocarcinom.

Cai X, Li S, Zeng X, Xu M, Wang Z, Singhi AD, Tang D, Li S, Yates NA, Yang D, Xie W. Cai X, et al. Cell Mol Gastroenterol Hepatol. 2023;16(3):473-495. doi: 10.1016/j.jcmgh.2023.05.003. Epub 2023 May 14. Cell Mol Gastroenterol Hepatol. 2023. PMID: 37192689 Free PMC article.

4

Inhibition of heme-thiolate monooxygenase CYP1B1 prevents hepatic stellate cell activation and liver fibrosis by accumulating trehalose.

Tung HC, Kim JW, Zhu J, Li S, Yan J, Liu Q, Koo I, Koshkin SA, Hao F, Zhong G, Xu M, Wang Z, Wang J, Huang Y, Xi Y, Cai X, Xu P, Ren S, Higashiyama T, Gonzalez FJ, Li S, Isoherranen N, Yang D, Ma X, Patterson AD, Xie W. Tung HC, et al. Among authors: cai x. Sci Transl Med. 2024 Sep 25;16(766):eadk8446. doi: 10.1126/scitranslmed.adk8446. Epub 2024 Sep 25. Sci Transl Med. 2024. PMID: 39321267

5

Gadd45b is required in part for the anti-obesity effect of constitutive androstane receptor (CAR).

Cai X, Feng Y, Xu M, Yu C, Xie W. Cai X, et al. Acta Pharm Sin B. 2021 Feb;11(2):434-441. doi: 10.1016/j.apsb.2020.08.015. Epub 2020 Sep 3. Acta Pharm Sin B. 2021. PMID: 33643822 Free PMC article.

6

Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis.

Xu P, Xi Y, Zhu J, Zhang M, Luka Z, Stolz DB, Cai X, Xie Y, Xu M, Ren S, Huang Z, Yang D, York JD, Ma X, Xie W. Xu P, et al. Among authors: cai x. Gastroenterology. 2021 Jul;161(1):271-286.e11. doi: 10.1053/j.gastro.2021.03.048. Epub 2021 Apr 2. Gastroenterology. 2021. PMID: 33819483 Free PMC article.

7

Chronic Activation of LXRα Sensitizes Mice to Hepatocellular Carcinoma.

Xie Y, Sun R, Gao L, Guan J, Wang J, Bell A, Zhu J, Zhang M, Xu M, Lu P, Cai X, Ren S, Xu P, Monga SP, Ma X, Yang D, Liu Y, Lu B, Xie W. Xie Y, et al. Among authors: cai x. Hepatol Commun. 2022 May;6(5):1123-1139. doi: 10.1002/hep4.1880. Epub 2022 Jan 3. Hepatol Commun. 2022. PMID: 34981658 Free PMC article.

8

Gestational Diabetes Sensitizes Mice to Future Metabolic Syndrome That Can Be Relieved by Activating CAR.

Feng Y, Xu D, Cai X, Xu M, Garbacz WG, Ren S, Jurczak MJ, Yu C, Wang H, Xie W. Feng Y, et al. Among authors: cai x. Endocrinology. 2022 Jul 1;163(7):bqac061. doi: 10.1210/endocr/bqac061. Endocrinology. 2022. PMID: 35524740

9

Sulfoconjugation of protein peptides and glycoproteins in physiology and diseases.

Xu P, Cai X, Guan X, Xie W. Xu P, et al. Among authors: cai x. Pharmacol Ther. 2023 Nov;251:108540. doi: 10.1016/j.pharmthera.2023.108540. Epub 2023 Sep 28. Pharmacol Ther. 2023. PMID: 37777160 Free PMC article. Review.

10

The xenobiotic receptors PXR and CAR in liver physiology, an update.

Cai X, Young GM, Xie W. Cai X, et al. Biochim Biophys Acta Mol Basis Dis. 2021 Jun 1;1867(6):166101. doi: 10.1016/j.bbadis.2021.166101. Epub 2021 Feb 15. Biochim Biophys Acta Mol Basis Dis. 2021. PMID: 33600998 Free PMC article. Review.

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