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Dependence of PAX3-FOXO1 chromatin occupancy on ETS1 at important disease-promoting genes exposes new targetable vulnerability in Fusion-Positive Rhabdomyosarcoma.
Hsieh J, Danis EP, Owens CR, Parrish JK, Nowling NL, Wolin AR, Purdy SC, Rosenbaum SR, Ivancevic AM, Chuong EB, Ford HL, Jedlicka P. Hsieh J, et al. Among authors: parrish jk. Oncogene. 2025 Jan;44(1):19-29. doi: 10.1038/s41388-024-03201-2. Epub 2024 Oct 24. Oncogene. 2025. PMID: 39448867 Free PMC article.
KDM5A and PHF2 positively control expression of pro-metastatic genes repressed by EWS/Fli1, and promote growth and metastatic properties in Ewing sarcoma.
McCann TS, Parrish JK, Hsieh J, Sechler M, Sobral LM, Self C, Jones KL, Goodspeed A, Costello JC, Jedlicka P. McCann TS, et al. Among authors: parrish jk. Oncotarget. 2020 Oct 27;11(43):3818-3831. doi: 10.18632/oncotarget.27737. eCollection 2020 Oct 27. Oncotarget. 2020. PMID: 33196691 Free PMC article.
The Jumonji-domain histone demethylase inhibitor JIB-04 deregulates oncogenic programs and increases DNA damage in Ewing Sarcoma, resulting in impaired cell proliferation and survival, and reduced tumor growth.
Parrish JK, McCann TS, Sechler M, Sobral LM, Ren W, Jones KL, Tan AC, Jedlicka P. Parrish JK, et al. Oncotarget. 2018 Sep 4;9(69):33110-33123. doi: 10.18632/oncotarget.26011. eCollection 2018 Sep 4. Oncotarget. 2018. PMID: 30237855 Free PMC article.
33 results