Eng C - Search Results

1

A structurally informed human protein-protein interactome reveals proteome-wide perturbations caused by disease mutations.

Xiong D, Qiu Y, Zhao J, Zhou Y, Lee D, Gupta S, Torres M, Lu W, Liang S, Kang JJ, Eng C, Loscalzo J, Cheng F, Yu H. Xiong D, et al. Among authors: eng c. Nat Biotechnol. 2024 Oct 24. doi: 10.1038/s41587-024-02428-4. Online ahead of print. Nat Biotechnol. 2024. PMID: 39448882

2

Comprehensive characterization of protein-protein interactions perturbed by disease mutations.

Cheng F, Zhao J, Wang Y, Lu W, Liu Z, Zhou Y, Martin WR, Wang R, Huang J, Hao T, Yue H, Ma J, Hou Y, Castrillon JA, Fang J, Lathia JD, Keri RA, Lightstone FC, Antman EM, Rabadan R, Hill DE, Eng C, Vidal M, Loscalzo J. Cheng F, et al. Among authors: eng c. Nat Genet. 2021 Mar;53(3):342-353. doi: 10.1038/s41588-020-00774-y. Epub 2021 Feb 8. Nat Genet. 2021. PMID: 33558758 Free PMC article.

3

PTEN Mutations Trigger Resistance to Immunotherapy.

Cheng F, Eng C. Cheng F, et al. Among authors: eng c. Trends Mol Med. 2019 Jun;25(6):461-463. doi: 10.1016/j.molmed.2019.03.003. Epub 2019 Mar 27. Trends Mol Med. 2019. PMID: 30928438

4

A genome-wide positioning systems network algorithm for in silico drug repurposing.

Cheng F, Lu W, Liu C, Fang J, Hou Y, Handy DE, Wang R, Zhao Y, Yang Y, Huang J, Hill DE, Vidal M, Eng C, Loscalzo J. Cheng F, et al. Among authors: eng c. Nat Commun. 2019 Aug 2;10(1):3476. doi: 10.1038/s41467-019-10744-6. Nat Commun. 2019. PMID: 31375661 Free PMC article.

5

Individualized genetic network analysis reveals new therapeutic vulnerabilities in 6,700 cancer genomes.

Liu C, Zhao J, Lu W, Dai Y, Hockings J, Zhou Y, Nussinov R, Eng C, Cheng F. Liu C, et al. Among authors: eng c. PLoS Comput Biol. 2020 Feb 26;16(2):e1007701. doi: 10.1371/journal.pcbi.1007701. eCollection 2020 Feb. PLoS Comput Biol. 2020. PMID: 32101536 Free PMC article.

6

My personal mutanome: a computational genomic medicine platform for searching network perturbing alleles linking genotype to phenotype.

Zhou Y, Zhao J, Fang J, Martin W, Li L, Nussinov R, Chan TA, Eng C, Cheng F. Zhou Y, et al. Among authors: eng c. Genome Biol. 2021 Jan 29;22(1):53. doi: 10.1186/s13059-021-02269-3. Genome Biol. 2021. PMID: 33514395 Free PMC article.

7

Target identification among known drugs by deep learning from heterogeneous networks.

Zeng X, Zhu S, Lu W, Liu Z, Huang J, Zhou Y, Fang J, Huang Y, Guo H, Li L, Trapp BD, Nussinov R, Eng C, Loscalzo J, Cheng F. Zeng X, et al. Among authors: eng c. Chem Sci. 2020 Jan 13;11(7):1775-1797. doi: 10.1039/c9sc04336e. Chem Sci. 2020. PMID: 34123272 Free PMC article.

8

Personal Mutanomes Meet Modern Oncology Drug Discovery and Precision Health.

Cheng F, Liang H, Butte AJ, Eng C, Nussinov R. Cheng F, et al. Among authors: eng c. Pharmacol Rev. 2019 Jan;71(1):1-19. doi: 10.1124/pr.118.016253. Epub 2018 Dec 13. Pharmacol Rev. 2019. PMID: 30545954 Free PMC article. Review.

9

Conformational Dynamics and Allosteric Regulation Landscapes of Germline PTEN Mutations Associated with Autism Compared to Those Associated with Cancer.

Smith IN, Thacker S, Seyfi M, Cheng F, Eng C. Smith IN, et al. Among authors: eng c. Am J Hum Genet. 2019 May 2;104(5):861-878. doi: 10.1016/j.ajhg.2019.03.009. Epub 2019 Apr 18. Am J Hum Genet. 2019. PMID: 31006514 Free PMC article.

10

A Systems Pharmacology Approach Uncovers Wogonoside as an Angiogenesis Inhibitor of Triple-Negative Breast Cancer by Targeting Hedgehog Signaling.

Huang Y, Fang J, Lu W, Wang Z, Wang Q, Hou Y, Jiang X, Reizes O, Lathia J, Nussinov R, Eng C, Cheng F. Huang Y, et al. Among authors: eng c. Cell Chem Biol. 2019 Aug 15;26(8):1143-1158.e6. doi: 10.1016/j.chembiol.2019.05.004. Epub 2019 Jun 6. Cell Chem Biol. 2019. PMID: 31178408 Free PMC article.

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