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Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.
Vantieghem T, Aslam NA, Osipov EM, Akele M, Van Belle S, Beelen S, Drexler M, Paulovcakova T, Lux V, Fearon D, Douangamath A, von Delft F, Christ F, Veverka V, Verwilst P, Van Aerschot A, Debyser Z, Strelkov SV. Vantieghem T, et al. Among authors: christ f. Eur J Med Chem. 2024 Oct 11;280:116960. doi: 10.1016/j.ejmech.2024.116960. Online ahead of print. Eur J Med Chem. 2024. PMID: 39461037
Targeting Virus-host Interactions of HIV Replication.
Weydert C, De Rijck J, Christ F, Debyser Z. Weydert C, et al. Among authors: christ f. Curr Top Med Chem. 2016;16(10):1167-90. doi: 10.2174/1568026615666150901115106. Curr Top Med Chem. 2016. PMID: 26324041 Review.
Interaction of transportin-SR2 with Ras-related nuclear protein (Ran) GTPase.
Taltynov O, Demeulemeester J, Christ F, De Houwer S, Tsirkone VG, Gerard M, Weeks SD, Strelkov SV, Debyser Z. Taltynov O, et al. Among authors: christ f. J Biol Chem. 2013 Aug 30;288(35):25603-25613. doi: 10.1074/jbc.M113.484345. Epub 2013 Jul 22. J Biol Chem. 2013. PMID: 23878195 Free PMC article.
Diketoacid chelating ligands as dual inhibitors of HIV-1 integration process.
Rogolino D, Carcelli M, Compari C, De Luca L, Ferro S, Fisicaro E, Rispoli G, Neamati N, Debyser Z, Christ F, Chimirri A. Rogolino D, et al. Among authors: christ f. Eur J Med Chem. 2014 May 6;78:425-30. doi: 10.1016/j.ejmech.2014.03.070. Epub 2014 Mar 25. Eur J Med Chem. 2014. PMID: 24704615
N-terminal half of transportin SR2 interacts with HIV integrase.
Tsirkone VG, Blokken J, De Wit F, Breemans J, De Houwer S, Debyser Z, Christ F, Strelkov SV. Tsirkone VG, et al. Among authors: christ f. J Biol Chem. 2017 Jun 9;292(23):9699-9710. doi: 10.1074/jbc.M117.777029. Epub 2017 Mar 29. J Biol Chem. 2017. PMID: 28356354 Free PMC article.
297 results