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19 results

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Page 1
Lipid-siRNA conjugate accesses perivascular transport and achieves durable knockdown throughout the central nervous system.
Sorets AG, Schwensen KR, Francini N, Kjar A, Abdulrahman AM, Shostak A, Katdare KA, Schoch KM, Cowell RP, Park JC, Ligocki AP, Ford WT, Ventura-Antunes L, Hoogenboezem EN, Prusky A, Castleberry M, Michell DL, Miller TM, Vickers KC, Schrag MS, Duvall CL, Lippmann ES. Sorets AG, et al. Among authors: francini n. bioRxiv [Preprint]. 2024 Sep 7:2024.06.09.598079. doi: 10.1101/2024.06.09.598079. bioRxiv. 2024. PMID: 38915549 Free PMC article. Preprint.
Covalent Polymer-RNA Conjugates for Potent Activation of the RIG-I Pathway.
Palmer CR, Pastora LE, Kimmel BR, Pagendarm HM, Kwiatkowski AJ, Stone PT, Arora K, Francini N, Fedorova O, Pyle AM, Wilson JT. Palmer CR, et al. Among authors: francini n. Adv Healthc Mater. 2024 Apr 22:e2303815. doi: 10.1002/adhm.202303815. Online ahead of print. Adv Healthc Mater. 2024. PMID: 38648653
Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy.
Hoogenboezem EN, Patel SS, Lo JH, Cavnar AB, Babb LM, Francini N, Gbur EF, Patil P, Colazo JM, Michell DL, Sanchez VM, McCune JT, Ma J, DeJulius CR, Lee LH, Rosch JC, Allen RM, Stokes LD, Hill JL, Vickers KC, Cook RS, Duvall CL. Hoogenboezem EN, et al. Among authors: francini n. Nat Commun. 2024 Feb 21;15(1):1581. doi: 10.1038/s41467-024-45609-0. Nat Commun. 2024. PMID: 38383524 Free PMC article.
Albumin-binding RNAi Conjugate for Carrier Free Treatment of Arthritis.
Colazo JM, Hoogenboezem EN, Keech MC, Francini N, Shah V, Yu F, Lo JH, Sorets AG, McCune JT, Cho H, DeJulius CR, Michell DL, Maerz T, Vickers KC, Gibson-Corley KN, Hasty KA, Crofford L, Cook RS, Duvall CL. Colazo JM, et al. Among authors: francini n. bioRxiv [Preprint]. 2023 Dec 28:2023.05.31.542971. doi: 10.1101/2023.05.31.542971. bioRxiv. 2023. PMID: 37333210 Free PMC article. Preprint.
Core polymer optimization of ternary siRNA nanoparticles enhances in vivo safety, pharmacokinetics, and tumor gene silencing.
Patel SS, Hoogenboezem EN, Yu F, DeJulius CR, Fletcher RB, Sorets AG, Cherry FK, Lo JH, Bezold MG, Francini N, d'Arcy R, Brasuell JE, Cook RS, Duvall CL. Patel SS, et al. Among authors: francini n. Biomaterials. 2023 Jun;297:122098. doi: 10.1016/j.biomaterials.2023.122098. Epub 2023 Mar 28. Biomaterials. 2023. PMID: 37031547 Free PMC article.
Structural Optimization of siRNA Conjugates for Albumin Binding Achieves Effective MCL1-Targeted Cancer Therapy.
Hoogenboezem EN, Patel SS, Cavnar AB, Lo JH, Babb LM, Francini N, Patil P, Colazo JM, Michell DL, Sanchez VM, McCune JT, Ma J, DeJulius CR, Lee LH, Rosch JC, Allen RM, Stokes LD, Hill JL, Vickers KC, Cook RS, Duvall CL. Hoogenboezem EN, et al. Among authors: francini n. bioRxiv [Preprint]. 2023 Feb 15:2023.02.14.528574. doi: 10.1101/2023.02.14.528574. bioRxiv. 2023. Update in: Nat Commun. 2024 Feb 21;15(1):1581. doi: 10.1038/s41467-024-45609-0. PMID: 36824780 Free PMC article. Updated. Preprint.
A Reactive Oxygen Species-Scavenging 'Stealth' Polymer, Poly(thioglycidyl glycerol), Outperforms Poly(ethylene glycol) in Protein Conjugates and Nanocarriers and Enhances Protein Stability to Environmental and Biological Stressors.
d'Arcy R, El Mohtadi F, Francini N, DeJulius CR, Back H, Gennari A, Geven M, Lopez-Cavestany M, Turhan ZY, Yu F, Lee JB, King MR, Kagan L, Duvall CL, Tirelli N. d'Arcy R, et al. Among authors: francini n. J Am Chem Soc. 2022 Nov 23;144(46):21304-21317. doi: 10.1021/jacs.2c09232. Epub 2022 Nov 11. J Am Chem Soc. 2022. PMID: 36367536 Free PMC article.
19 results