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Chemotherapy combined with immune checkpoint inhibitors may overcome the detrimental effect of high neutrophil-to-lymphocyte ratio prior to treatment in esophageal cancer patients.
Hirasawa Y, Kubota Y, Mura E, Suzuki R, Tsurui T, Iriguchi N, Ishiguro T, Ohkuma R, Shimokawa M, Ariizumi H, Horiike A, Wada S, Yamashita T, Ariyoshi T, Goto S, Otsuka K, Murakami M, Kiuchi Y, Yoshimura K, Tsunoda T. Hirasawa Y, et al. Among authors: ohkuma r. Front Oncol. 2024 Oct 11;14:1449941. doi: 10.3389/fonc.2024.1449941. eCollection 2024. Front Oncol. 2024. PMID: 39464714 Free PMC article.
[Multihospital randomized study on adjuvant chemotherapy with mitomycin C and futraful or UFT in gastric cancer (Part 1). Comparison between futraful and UFT. North Kyushu Co-operative Study Group for Cancer Chemotherapy)].
Arima S, Simura H, Yamanouchi A, Fukuyama N, Hisatsugu T, Yamamoto H, Ohsato K, Ohkuma R, Nakamura Y, Abe R, et al. Arima S, et al. Among authors: ohkuma r. Gan To Kagaku Ryoho. 1987 Aug;14(8):2524-31. Gan To Kagaku Ryoho. 1987. PMID: 3113340 Clinical Trial. Japanese.
Rabeprazole intake does not affect systemic exposure to capecitabine and its metabolites, 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, and 5-fluorouracil.
Sekido M, Fujita KI, Kubota Y, Ishida H, Takahashi T, Ohkuma R, Tsunoda T, Ishikawa F, Shibanuma M, Sasaki Y. Sekido M, et al. Among authors: ohkuma r. Cancer Chemother Pharmacol. 2019 Jun;83(6):1127-1135. doi: 10.1007/s00280-019-03837-y. Epub 2019 Apr 9. Cancer Chemother Pharmacol. 2019. PMID: 30972456
Plasma Levels of Soluble PD-L1 Correlate With Tumor Regression in Patients With Lung and Gastric Cancer Treated With Immune Checkpoint Inhibitors.
Ando K, Hamada K, Watanabe M, Ohkuma R, Shida M, Onoue R, Kubota Y, Matsui H, Ishiguro T, Hirasawa Y, Ariizumi H, Tsurutani J, Yoshimura K, Tsunoda T, Kobayashi S, Wada S. Ando K, et al. Among authors: ohkuma r. Anticancer Res. 2019 Sep;39(9):5195-5201. doi: 10.21873/anticanres.13716. Anticancer Res. 2019. PMID: 31519633
High expression of olfactomedin-4 is correlated with chemoresistance and poor prognosis in pancreatic cancer.
Ohkuma R, Yada E, Ishikawa S, Komura D, Ishizaki H, Tamada K, Kubota Y, Hamada K, Ishida H, Hirasawa Y, Ariizumi H, Satoh E, Shida M, Watanabe M, Onoue R, Ando K, Tsurutani J, Yoshimura K, Yokobori T, Sasada T, Aoki T, Murakami M, Norose T, Ohike N, Takimoto M, Izumizaki M, Kobayashi S, Tsunoda T, Wada S. Ohkuma R, et al. PLoS One. 2020 Jan 10;15(1):e0226707. doi: 10.1371/journal.pone.0226707. eCollection 2020. PLoS One. 2020. PMID: 31923206 Free PMC article.
Variants of carboxylesterase 1 have no impact on capecitabine pharmacokinetics and toxicity in capecitabine plus oxaliplatin treated-colorectal cancer patients.
Matsumoto N, Kubota Y, Ishida H, Sekido M, Ohkuma R, Ishiguro T, Hirasawa Y, Ariizumi H, Tsunoda T, Ikusue T, Kobayashi K, Hisamatsu A, Toshima H, Shimada K, Fujita KI. Matsumoto N, et al. Among authors: ohkuma r. Cancer Chemother Pharmacol. 2020 Jun;85(6):1119-1128. doi: 10.1007/s00280-020-04087-z. Epub 2020 May 26. Cancer Chemother Pharmacol. 2020. PMID: 32458030
High expression levels of polymeric immunoglobulin receptor are correlated with chemoresistance and poor prognosis in pancreatic cancer.
Ohkuma R, Yada E, Ishikawa S, Komura D, Kubota Y, Hamada K, Horiike A, Ishiguro T, Hirasawa Y, Ariizumi H, Shida M, Watanabe M, Onoue R, Ando K, Tsurutani J, Yoshimura K, Sasada T, Aoki T, Murakami M, Norose T, Ohike N, Takimoto M, Kobayashi S, Tsunoda T, Wada S. Ohkuma R, et al. Oncol Rep. 2020 Jul;44(1):252-262. doi: 10.3892/or.2020.7610. Epub 2020 May 11. Oncol Rep. 2020. PMID: 32627041 Free PMC article.
A high number of PD-L1+ CD14+ monocytes in peripheral blood is correlated with shorter survival in patients receiving immune checkpoint inhibitors.
Ando K, Hamada K, Shida M, Ohkuma R, Kubota Y, Horiike A, Matsui H, Ishiguro T, Hirasawa Y, Ariizumi H, Watanabe M, Onoue R, Tsurutani J, Yoshimura K, Tsunoda T, Kobayashi S, Wada S. Ando K, et al. Among authors: ohkuma r. Cancer Immunol Immunother. 2021 Feb;70(2):337-348. doi: 10.1007/s00262-020-02686-6. Epub 2020 Aug 5. Cancer Immunol Immunother. 2021. PMID: 32757055 Free PMC article.
60 results