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Nanoparticle-based itaconate treatment recapitulates low-cholesterol/low-fat diet-induced atherosclerotic plaque resolution.
Hong NE, Chaplin A, Di L, Ravodina A, Bevan GH, Gao H, Asase C, Gangwar RS, Cameron MJ, Mignery M, Cherepanova O, Finn AV, Nayak L, Pieper AA, Maiseyeu A. Hong NE, et al. Among authors: nayak l. Cell Rep. 2024 Oct 27;43(11):114911. doi: 10.1016/j.celrep.2024.114911. Online ahead of print. Cell Rep. 2024. PMID: 39466775 Free article.
A targetable pathway in neutrophils mitigates both arterial and venous thrombosis.
Nayak L, Sweet DR, Thomas A, Lapping SD, Kalikasingh K, Madera A, Vinayachandran V, Padmanabhan R, Vasudevan NT, Myers JT, Huang AY, Schmaier A, Mackman N, Liao X, Maiseyeu A, Jain MK. Nayak L, et al. Sci Transl Med. 2022 Aug 31;14(660):eabj7465. doi: 10.1126/scitranslmed.abj7465. Epub 2022 Aug 31. Sci Transl Med. 2022. PMID: 36044595 Free PMC article.
Endothelial Kruppel-like factor 4 protects against atherothrombosis in mice.
Zhou G, Hamik A, Nayak L, Tian H, Shi H, Lu Y, Sharma N, Liao X, Hale A, Boerboom L, Feaver RE, Gao H, Desai A, Schmaier A, Gerson SL, Wang Y, Atkins GB, Blackman BR, Simon DI, Jain MK. Zhou G, et al. Among authors: nayak l. J Clin Invest. 2012 Dec;122(12):4727-31. doi: 10.1172/JCI66056. Epub 2012 Nov 19. J Clin Invest. 2012. PMID: 23160196 Free PMC article.
Myeloid Krüppel-like factor 2 is a critical regulator of metabolic inflammation.
Sweet DR, Vasudevan NT, Fan L, Booth CE, Keerthy KS, Liao X, Vinayachandran V, Takami Y, Tugal D, Sharma N, Chan ER, Zhang L, Qing Y, Gerson SL, Fu C, Wynshaw-Boris A, Sangwung P, Nayak L, Holvoet P, Matoba K, Lu Y, Zhou G, Jain MK. Sweet DR, et al. Among authors: nayak l. Nat Commun. 2020 Nov 18;11(1):5872. doi: 10.1038/s41467-020-19760-3. Nat Commun. 2020. PMID: 33208733 Free PMC article.
316 results