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Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aging.
Occean JR, Yang N, Sun Y, Dawkins MS, Munk R, Belair C, Dar S, Anerillas C, Wang L, Shi C, Dunn C, Bernier M, Price NL, Kim JS, Cui CY, Fan J, Bhattacharyya M, De S, Maragkakis M, de Cabo R, Sidoli S, Sen P. Occean JR, et al. Among authors: maragkakis m. Nat Commun. 2024 Jul 28;15(1):6357. doi: 10.1038/s41467-024-50725-y. Nat Commun. 2024. PMID: 39069555 Free PMC article.
Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD.
Seddighi S, Qi YA, Brown AL, Wilkins OG, Bereda C, Belair C, Zhang YJ, Prudencio M, Keuss MJ, Khandeshi A, Pickles S, Kargbo-Hill SE, Hawrot J, Ramos DM, Yuan H, Roberts J, Sacramento EK, Shah SI, Nalls MA, Colón-Mercado JM, Reyes JF, Ryan VH, Nelson MP, Cook CN, Li Z, Screven L, Kwan JY, Mehta PR, Zanovello M, Hallegger M, Shantaraman A, Ping L, Koike Y, Oskarsson B, Staff NP, Duong DM, Ahmed A, Secrier M, Ule J, Jacobson S, Reich DS, Rohrer JD, Malaspina A, Dickson DW, Glass JD, Ori A, Seyfried NT, Maragkakis M, Petrucelli L, Fratta P, Ward ME. Seddighi S, et al. Among authors: maragkakis m. Sci Transl Med. 2024 Feb 14;16(734):eadg7162. doi: 10.1126/scitranslmed.adg7162. Epub 2024 Feb 14. Sci Transl Med. 2024. PMID: 38277467 Free PMC article.
Senescence suppresses the integrated stress response and activates a stress-enhanced secretory phenotype.
Payea MJ, Dar SA, Anerillas C, Martindale JL, Belair C, Munk R, Malla S, Fan J, Piao Y, Yang X, Rehman A, Banskota N, Abdelmohsen K, Gorospe M, Maragkakis M. Payea MJ, et al. Among authors: maragkakis m. bioRxiv [Preprint]. 2023 Nov 18:2023.04.12.536613. doi: 10.1101/2023.04.12.536613. bioRxiv. 2023. Update in: Mol Cell. 2024 Oct 24:S1097-2765(24)00826-8. doi: 10.1016/j.molcel.2024.10.003. PMID: 37609272 Free PMC article. Updated. Preprint.
41 results