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CYP5122A1 encodes an essential sterol C4-methyl oxidase in Leishmania donovani and determines the antileishmanial activity of antifungal azoles.
Jin Y, Basu S, Feng M, Ning Y, Munasinghe I, Joachim AM, Li J, Qin L, Madden R, Burks H, Gao P, Wu JQ, Sheikh SW, Joice AC, Perera C, Werbovetz KA, Zhang K, Wang MZ. Jin Y, et al. Among authors: gao p. Nat Commun. 2024 Oct 31;15(1):9409. doi: 10.1038/s41467-024-53790-5. Nat Commun. 2024. PMID: 39482311 Free PMC article.
CYP5122A1 encodes an essential sterol C4-methyl oxidase in Leishmania donovani and determines the antileishmanial activity of antifungal azoles.
Jin Y, Basu S, Feng M, Ning Y, Munasinghe I, Joachim AM, Li J, Madden R, Burks H, Gao P, Perera C, Werbovetz KA, Zhang K, Wang MZ. Jin Y, et al. Among authors: gao p. Res Sq [Preprint]. 2023 Jul 27:rs.3.rs-3185204. doi: 10.21203/rs.3.rs-3185204/v1. Res Sq. 2023. Update in: Nat Commun. 2024 Oct 31;15(1):9409. doi: 10.1038/s41467-024-53790-5 PMID: 37546914 Free PMC article. Updated. Preprint.
Synthesis and biological characterization of an orally bioavailable lactate dehydrogenase-A inhibitor against pancreatic cancer.
Sharma H, Mondal S, Urquiza U, Esparza C, Bartlett S, Santa-Pinter L, Hill H, White M, Sharma P, Luckett-Chastain L, Cooper A, Rasel M, Gao P, Battaile KP, Shukla SK, Lovell S, Ihnat MA. Sharma H, et al. Among authors: gao p. Eur J Med Chem. 2024 Sep 5;275:116598. doi: 10.1016/j.ejmech.2024.116598. Epub 2024 Jun 17. Eur J Med Chem. 2024. PMID: 38925013 Free article.
Mutation of a highly conserved isoleucine residue in loop 2 of several β-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental for replication.
Kerr CM, Pfannenstiel JJ, Alhammad YM, O'Connor JJ, Ghimire R, Shrestha R, Khattabi R, Saenjamsai P, Parthasarathy S, McDonald PR, Gao P, Johnson DK, More S, Roy A, Channappanavar R, Fehr AR. Kerr CM, et al. Among authors: gao p. J Virol. 2024 Nov 19;98(11):e0131324. doi: 10.1128/jvi.01313-24. Epub 2024 Oct 10. J Virol. 2024. PMID: 39387584 Free article.
Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins.
Lan L, Liu H, Smith AR, Appelman C, Yu J, Larsen S, Marquez RT, Wu X, Liu FY, Gao P, Gowthaman R, Karanicolas J, De Guzman RN, Rogers S, Aubé J, Neufeld KL, Xu L. Lan L, et al. Among authors: gao p. BMC Cancer. 2018 Aug 10;18(1):809. doi: 10.1186/s12885-018-4704-z. BMC Cancer. 2018. PMID: 30097032 Free PMC article.
HSV-1 ICP0 dimer domain adopts a novel β-barrel fold.
McCloskey E, Kashipathy M, Cooper A, Gao P, Johnson DK, Battaile KP, Lovell S, Davido DJ. McCloskey E, et al. Among authors: gao p. Proteins. 2024 Jul;92(7):830-841. doi: 10.1002/prot.26673. Epub 2024 Feb 19. Proteins. 2024. PMID: 38372168
Recognition of single-stranded nucleic acids by small-molecule splicing modulators.
Tang Z, Akhter S, Ramprasad A, Wang X, Reibarkh M, Wang J, Aryal S, Thota SS, Zhao J, Douglas JT, Gao P, Holmstrom ED, Miao Y, Wang J. Tang Z, et al. Among authors: gao p. Nucleic Acids Res. 2021 Aug 20;49(14):7870-7883. doi: 10.1093/nar/gkab602. Nucleic Acids Res. 2021. PMID: 34283224 Free PMC article.
7,239 results