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Page 1
Methylation Mesa define functional regulatory elements for targeted gene activation.
Liu YV, Suryatenggara J, Wong H, Jayasinghe MK, Tang JP, Tan HK, Kwon J, Zhou Q, Ummarino S, Ebralidze AK, Le MTN, Doench JG, Chai L, Benoukraf T, Hiwase D, Thomas D, Di Ruscio A, Tenen DG, Bassal MA. Liu YV, et al. Among authors: di ruscio a. Res Sq [Preprint]. 2024 Oct 16:rs.3.rs-4359582. doi: 10.21203/rs.3.rs-4359582/v1. Res Sq. 2024. PMID: 39483908 Free PMC article. Preprint.
Bi-functional CpG-STAT3 decoy oligonucleotide triggers multilineage differentiation of acute myeloid leukemia in mice.
Wang D, Kaniowski D, Jacek K, Su YL, Yu C, Hall J, Li H, Feng M, Hui S, Kaminska B, DeFranciscis V, Esposito CL, DiRuscio A, Zhang B, Marcucci G, Kuo YH, Kortylewski M. Wang D, et al. Mol Ther Nucleic Acids. 2024 Jul 16;35(3):102268. doi: 10.1016/j.omtn.2024.102268. eCollection 2024 Sep 10. Mol Ther Nucleic Acids. 2024. PMID: 39171140 Free PMC article.
Editorial: DNA methylation: The aging clock.
Ghinassi B, Matarazzo MR, Di Ruscio A. Ghinassi B, et al. Among authors: di ruscio a. Front Cell Dev Biol. 2023 Mar 15;11:1164429. doi: 10.3389/fcell.2023.1164429. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 37009473 Free PMC article. No abstract available.
Targeted systematic evolution of an RNA platform neutralizing DNMT1 function and controlling DNA methylation.
Esposito CL, Autiero I, Sandomenico A, Li H, Bassal MA, Ibba ML, Wang D, Rinaldi L, Ummarino S, Gaggi G, Borchiellini M, Swiderski P, Ruvo M, Catuogno S, Ebralidze AK, Kortylewski M, de Franciscis V, Di Ruscio A. Esposito CL, et al. Among authors: di ruscio a. Nat Commun. 2023 Jan 6;14(1):99. doi: 10.1038/s41467-022-35222-4. Nat Commun. 2023. PMID: 36609400 Free PMC article.
NAD Modulates DNA Methylation and Cell Differentiation.
Ummarino S, Hausman C, Gaggi G, Rinaldi L, Bassal MA, Zhang Y, Seelam AJ, Kobayashi IS, Borchiellini M, Ebralidze AK, Ghinassi B, Trinh BQ, Kobayashi SS, Di Ruscio A. Ummarino S, et al. Among authors: di ruscio a. Cells. 2021 Nov 2;10(11):2986. doi: 10.3390/cells10112986. Cells. 2021. PMID: 34831209 Free PMC article.
Pseudogene-mediated DNA demethylation leads to oncogene activation.
Kwon J, Liu YV, Gao C, Bassal MA, Jones AI, Yang J, Chen Z, Li Y, Yang H, Chen L, Di Ruscio A, Tay Y, Chai L, Tenen DG. Kwon J, et al. Among authors: di ruscio a. Sci Adv. 2021 Oct;7(40):eabg1695. doi: 10.1126/sciadv.abg1695. Epub 2021 Oct 1. Sci Adv. 2021. PMID: 34597139 Free PMC article.
Core-binding factor leukemia hijacks the T-cell-prone PU.1 antisense promoter.
van der Kouwe E, Heller G, Czibere A, Pulikkan JA, Agreiter C, Castilla LH, Delwel R, Di Ruscio A, Ebralidze AK, Forte M, Grebien F, Heyes E, Kazianka L, Klinger J, Kornauth C, Le T, Lind K, Barbosa IAM, Pemovska T, Pichler A, Schmolke AS, Schweicker CM, Sill H, Sperr WR, Spittler A, Surapally S, Trinh BQ, Valent P, Vanura K, Welner RS, Zuber J, Tenen DG, Staber PB. van der Kouwe E, et al. Among authors: di ruscio a. Blood. 2021 Oct 14;138(15):1345-1358. doi: 10.1182/blood.2020008971. Blood. 2021. PMID: 34010414 Free PMC article.
Myeloid lncRNA LOUP mediates opposing regulatory effects of RUNX1 and RUNX1-ETO in t(8;21) AML.
Trinh BQ, Ummarino S, Zhang Y, Ebralidze AK, Bassal MA, Nguyen TM, Heller G, Coffey R, Tenen DE, van der Kouwe E, Fabiani E, Gurnari C, Wu CS, Angarica VE, Yang H, Chen S, Zhang H, Thurm AR, Marchi F, Levantini E, Staber PB, Zhang P, Voso MT, Pandolfi PP, Kobayashi SS, Chai L, Di Ruscio A, Tenen DG. Trinh BQ, et al. Among authors: di ruscio a. Blood. 2021 Oct 14;138(15):1331-1344. doi: 10.1182/blood.2020007920. Blood. 2021. PMID: 33971010 Free PMC article.
41 results