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Integrated systems biology identifies disruptions in mitochondrial function and metabolism as key contributors to heart failure with preserved ejection fraction (HFpEF).
Gibb AA, LaPenna K, Gaspar RB, Latchman NR, Tan Y, Choya-Foces C, Doiron JE, Li Z, Xia H, Lazaropoulos MP, Conwell M, Sharp TE 3rd, Goodchild TT, Lefer DJ, Elrod JW. Gibb AA, et al. Among authors: elrod jw. bioRxiv [Preprint]. 2024 Oct 25:2024.10.25.619450. doi: 10.1101/2024.10.25.619450. bioRxiv. 2024. PMID: 39484400 Free PMC article. Preprint.
Mitochondrial H2S Regulates BCAA Catabolism in Heart Failure.
Li Z, Xia H, Sharp TE 3rd, LaPenna KB, Elrod JW, Casin KM, Liu K, Calvert JW, Chau VQ, Salloum FN, Xu S, Xian M, Nagahara N, Goodchild TT, Lefer DJ. Li Z, et al. Among authors: elrod jw. Circ Res. 2022 Jul 22;131(3):222-235. doi: 10.1161/CIRCRESAHA.121.319817. Epub 2022 Jun 14. Circ Res. 2022. PMID: 35701874 Free PMC article.
Mitochondria in Pathological Cardiac Remodeling.
Lazaropoulos MP, Elrod JW. Lazaropoulos MP, et al. Among authors: elrod jw. Curr Opin Physiol. 2022 Feb;25:100489. doi: 10.1016/j.cophys.2022.100489. Epub 2022 Feb 19. Curr Opin Physiol. 2022. PMID: 35274068 Free PMC article.
Hydrogen Sulfide Modulates Endothelial-Mesenchymal Transition in Heart Failure.
Li Z, Xia H, Sharp TE 3rd, LaPenna KB, Katsouda A, Elrod JW, Pfeilschifter J, Beck KF, Xu S, Xian M, Goodchild TT, Papapetropoulos A, Lefer DJ. Li Z, et al. Among authors: elrod jw. Circ Res. 2023 Jan 20;132(2):154-166. doi: 10.1161/CIRCRESAHA.122.321326. Epub 2022 Dec 28. Circ Res. 2023. PMID: 36575984 Free PMC article.
Molecular Signature of HFpEF: Systems Biology in a Cardiac-Centric Large Animal Model.
Gibb AA, Murray EK, Eaton DM, Huynh AT, Tomar D, Garbincius JF, Kolmetzky DW, Berretta RM, Wallner M, Houser SR, Elrod JW. Gibb AA, et al. Among authors: elrod jw. JACC Basic Transl Sci. 2021 Aug 23;6(8):650-672. doi: 10.1016/j.jacbts.2021.07.004. eCollection 2021 Aug. JACC Basic Transl Sci. 2021. PMID: 34466752 Free PMC article.
113 results