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Integrated systems biology identifies disruptions in mitochondrial function and metabolism as key contributors to heart failure with preserved ejection fraction (HFpEF).
Gibb AA, LaPenna K, Gaspar RB, Latchman NR, Tan Y, Choya-Foces C, Doiron JE, Li Z, Xia H, Lazaropoulos MP, Conwell M, Sharp TE 3rd, Goodchild TT, Lefer DJ, Elrod JW. Gibb AA, et al. Among authors: goodchild tt. bioRxiv [Preprint]. 2024 Oct 25:2024.10.25.619450. doi: 10.1101/2024.10.25.619450. bioRxiv. 2024. PMID: 39484400 Free PMC article. Preprint.
Reduced Hydrogen Sulfide Bioavailability Contributes to Cardiometabolic Heart Failure with Preserved Ejection Fraction.
Doiron JE, Elbatreek MH, Xia H, Yu X, Wilson Tang WH, LaPenna KB, Sharp TE, Goodchild TT, Xian M, Xu S, Quiriarte H, Allerton TD, Zagouras A, Wilcox J, Shah SJ, Pfeilschifter J, Beck KF, Li Z, Lefer DJ. Doiron JE, et al. Among authors: goodchild tt. bioRxiv [Preprint]. 2024 Sep 19:2024.09.16.613349. doi: 10.1101/2024.09.16.613349. bioRxiv. 2024. PMID: 39345440 Free PMC article. Preprint.
Adjunctive therapy with an oral H2S donor provides additional therapeutic benefit beyond SGLT2 inhibition in cardiometabolic heart failure with preserved ejection fraction.
Doiron JE, Xia H, Yu X, Nevins AR, LaPenna KB, Sharp TE 3rd, Goodchild TT, Allerton TD, Elgazzaz M, Lazartigues E, Shah SJ, Li Z, Lefer DJ. Doiron JE, et al. Among authors: goodchild tt. Br J Pharmacol. 2024 Nov;181(21):4294-4310. doi: 10.1111/bph.16493. Epub 2024 Jul 9. Br J Pharmacol. 2024. PMID: 38982742
Combination Sodium Nitrite and Hydralazine Therapy Attenuates Heart Failure With Preserved Ejection Fraction Severity in a "2-Hit" Murine Model.
LaPenna KB, Li Z, Doiron JE, Sharp TE 3rd, Xia H, Moles K, Koul K, Wang JS, Polhemus DJ, Goodchild TT, Patel RB, Shah SJ, Lefer DJ. LaPenna KB, et al. Among authors: goodchild tt. J Am Heart Assoc. 2023 Feb 21;12(4):e028480. doi: 10.1161/JAHA.122.028480. Epub 2023 Feb 8. J Am Heart Assoc. 2023. PMID: 36752224 Free PMC article.
Hydrogen Sulfide Modulates Endothelial-Mesenchymal Transition in Heart Failure.
Li Z, Xia H, Sharp TE 3rd, LaPenna KB, Katsouda A, Elrod JW, Pfeilschifter J, Beck KF, Xu S, Xian M, Goodchild TT, Papapetropoulos A, Lefer DJ. Li Z, et al. Among authors: goodchild tt. Circ Res. 2023 Jan 20;132(2):154-166. doi: 10.1161/CIRCRESAHA.122.321326. Epub 2022 Dec 28. Circ Res. 2023. PMID: 36575984 Free PMC article.
Mitochondrial H2S Regulates BCAA Catabolism in Heart Failure.
Li Z, Xia H, Sharp TE 3rd, LaPenna KB, Elrod JW, Casin KM, Liu K, Calvert JW, Chau VQ, Salloum FN, Xu S, Xian M, Nagahara N, Goodchild TT, Lefer DJ. Li Z, et al. Among authors: goodchild tt. Circ Res. 2022 Jul 22;131(3):222-235. doi: 10.1161/CIRCRESAHA.121.319817. Epub 2022 Jun 14. Circ Res. 2022. PMID: 35701874 Free PMC article.
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