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Page 1
Integrated systems biology identifies disruptions in mitochondrial function and metabolism as key contributors to heart failure with preserved ejection fraction (HFpEF).
Gibb AA, LaPenna K, Gaspar RB, Latchman NR, Tan Y, Choya-Foces C, Doiron JE, Li Z, Xia H, Lazaropoulos MP, Conwell M, Sharp TE 3rd, Goodchild TT, Lefer DJ, Elrod JW. Gibb AA, et al. Among authors: lazaropoulos mp. bioRxiv [Preprint]. 2024 Oct 25:2024.10.25.619450. doi: 10.1101/2024.10.25.619450. bioRxiv. 2024. PMID: 39484400 Free PMC article. Preprint.
TMEM65 regulates NCLX-dependent mitochondrial calcium efflux.
Garbincius JF, Salik O, Cohen HM, Choya-Foces C, Mangold AS, Makhoul AD, Schmidt AE, Khalil DY, Doolittle JJ, Wilkinson AS, Murray EK, Lazaropoulos MP, Hildebrand AN, Tomar D, Elrod JW. Garbincius JF, et al. Among authors: lazaropoulos mp. bioRxiv [Preprint]. 2023 Oct 9:2023.10.06.561062. doi: 10.1101/2023.10.06.561062. bioRxiv. 2023. PMID: 37873405 Free PMC article. Preprint.
Glutamine uptake and catabolism is required for myofibroblast formation and persistence.
Gibb AA, Huynh AT, Gaspar RB, Ploesch TL, Lombardi AA, Lorkiewicz PK, Lazaropoulos MP, Bedi K, Arany Z, Margulies KB, Hill BG, Elrod JW. Gibb AA, et al. Among authors: lazaropoulos mp. J Mol Cell Cardiol. 2022 Nov;172:78-89. doi: 10.1016/j.yjmcc.2022.08.002. Epub 2022 Aug 18. J Mol Cell Cardiol. 2022. PMID: 35988357 Free PMC article.
Mitochondria in Pathological Cardiac Remodeling.
Lazaropoulos MP, Elrod JW. Lazaropoulos MP, et al. Curr Opin Physiol. 2022 Feb;25:100489. doi: 10.1016/j.cophys.2022.100489. Epub 2022 Feb 19. Curr Opin Physiol. 2022. PMID: 35274068 Free PMC article.
Association of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging.
Kapogiannis D, Mustapic M, Shardell MD, Berkowitz ST, Diehl TC, Spangler RD, Tran J, Lazaropoulos MP, Chawla S, Gulyani S, Eitan E, An Y, Huang CW, Oh ES, Lyketsos CG, Resnick SM, Goetzl EJ, Ferrucci L. Kapogiannis D, et al. Among authors: lazaropoulos mp. JAMA Neurol. 2019 Nov 1;76(11):1340-1351. doi: 10.1001/jamaneurol.2019.2462. JAMA Neurol. 2019. PMID: 31305918 Free PMC article.
Spontaneous ATM Gene Reversion in A-T iPSC to Produce an Isogenic Cell Line.
Lin L, Swerdel MR, Lazaropoulos MP, Hoffman GS, Toro-Ramos AJ, Wright J, Lederman H, Chen J, Moore JC, Hart RP. Lin L, et al. Among authors: lazaropoulos mp. Stem Cell Reports. 2015 Dec 8;5(6):1097-1108. doi: 10.1016/j.stemcr.2015.10.010. Epub 2015 Nov 19. Stem Cell Reports. 2015. PMID: 26677768 Free PMC article.